Genome Medicine | Volume 1 Issue 5

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		Volume 1 Issue 5
		Comment
		Musings Musings on genome medicine: cancer genetics and the promise of effective treatment David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:49 (6 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Our understanding of the genetics and cell biology of cancer continues to grow, and with this understanding will come the drugs that will help to make cancer a manageable, if not a curable, disease.
		Commentary The futility of genomic counseling: essential role of electronic health records John Belmont, Amy L McGuire Genome Medicine 2009, 1:48 (8 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Integration of a dynamic uniform electronic health record is essential for the success of patient counseling on the basis of genome-wide data.
		Commentary Studying chromosome-wide transcriptional networks: new insights into disease? Philipp Kapranov Genome Medicine 2009, 1:50 (11 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent findings challenge the notion of a gene as a separate, discrete genomic unit, and transcriptional networks will be key to understanding sequence variation data as well as to identifying new biomarkers of disease.
		Review
		Review Molecular genetics of atrial fibrillation Samir B Damani, Eric J Topol Genome Medicine 2009, 1:54 (22 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Through genomic approaches and technologies, a region on 4q25 has been identified as a common susceptibility factor for atrial fibrillation and the PITX2 gene has been identified as the causal variant; more such variants will soon be identified.
		Review Advances in the identification and analysis of allele-specific expression Christopher G Bell, Stephan Beck Genome Medicine 2009, 1:56 (29 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Novel technologies that permit simultaneous genomic, epigenomic and expression analyses will improve our understanding of the biological and pathological processes mediated by allele-specific expression. leading to a better understanding of disease.
		Minireview *Germline and somatic JAK2* mutations and susceptibility to chronic myeloproliferative neoplasms** Lynn R Goldin, Magnus Björkholm, Sigurdur Y Kristinsson, Jan Samuelsson, Ola Landgren Genome Medicine 2009, 1:55 (29 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The strong association between germline polymorphisms and myeloproliferative neoplasms in patients positive for a mutation in the JAK2 gene may provide new possibilities for the pathogenesis of these cancers.
		Report
		Meeting report Genetics and Genomics of Infectious Diseases: advancing our understanding of host/pathogens and their interactions Ninghan Yang, Martin L Hibberd Genome Medicine 2009, 1:52 (18 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Genetics and Genomics of Infectious Diseases conference, Singapore, 21-24 March 2009.
		Meeting report Novel insights into proteomic technologies and their clinical perspective Gunnar Dittmar, Matthias Selbach Genome Medicine 2009, 1:53 (21 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Proteomic Forum 2009 conference, Berlin, Germany, 29 March to 2 April, 2009.
		Correspondence
		Correspondence Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease Kaisa Silander, Hua Tang, Sean Myles, Eveliina Jakkula, Nicholas J Timpson, Luigi Cavalli-Sforza, Leena Peltonen Genome Medicine 2009, 1:51 (12 May 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The protective allele for diabetes and the risk allele for coronary heart disease at the 9p21.3 locus have varying haplotype frequencies across 51 populations, implying very different population histories and highlighting the need to consider allelic background data for replication studies of genetic associations.