Table 4

Classification of proteins with statistically significant changes based on Gene Ontology

Protein

Log2 ratio year one relative to baseline

P-value

Blood coagulation and inflammation

Vitronectin (VTN)

0.374

9.27E-08

Ceruloplasmin (CP) [59]

0.789

1.51E-06

Plasminogen (PLG) [51]

0.307

1.50E-06

Kininogen (KNG1) [52]

0.265

2.89E-05

Coagulation factor XII (F12) [52]

0.364

4.64E-05

Coagulation factor IX (F9)

0.558

8.34E-05

Coagulation factor X (F10)

0.332

0.00029

Carboxypeptidase N, polypeptide 1 (CPN1)

0.288

0.0002

Platelet basic protein (PPBP)

0.273

0.00363

Tissue factor pathway inhibitor (TFPI) [51]

-0.267

0.01152

Fibrinogen gamma chain (FGG)

0.273

0.01848

Matrix metalloproteinase 2 (MMP2)

-0.681

0.03019

Protein Z, vitamin K-dependent plasma glycoprotein (PROZ)

0.676

0.03401

Hyaluronan-binding protein 2 (HABP2)

0.324

0.00029

Metabolism

Sex hormone binding globulin (SHBG) [68]

1.381

2.30E-07

Insulin-like growth factor binding protein 1 (IGFBP1) [18]

1.318

3.82E-05

Insulin-like growth factor binding protein 4 (IGFBP4) [18]

0.773

8.61E-06

Apolipoprotein A-II (APOA2) [57]

0.379

4.06E-06

Vitamin D binding protein (GC) [59]

0.298

5.82E-06

Apolipoprotein D (APOD) [57]

-0.396

0.00133

Insulin-like growth factor binding protein 6 (IGFBP6)

0.303

0.00225

Insulin-like growth factor (IGF1) [18]

-0.410

0.00366

Proprotein convertase subtilisin kexin 9 (PCSK9)

0.385

0.02486

Serpin peptidase inhibitor, clade A, member 6 (SERPINA6)

0.377

0.02446

Osteogenesis

Fetuin B (FETUB)

0.748

2.81E-07

Macrophage stimulating protein 1 (MST1)

0.546

0.00154

Collagen type 1, alpha 1 (COL1A1)

-0.494

0.00023

Tolloid-like protein 1, bone morphogenetic protein 1 (TLL1)

-1.150

0.0467

Neurogenic locus notch homolog protein 2 (NOTCH2)

-0.289

0.01946

Neurogenic locus notch homolog protein 3 (NOTCH3)

-0.622

0.02133

Fetuin A (AHSG) [59]

0.281

1.16E-06

Cell growth

Inhibin, beta E (INHBE)

0.472

0.01866

Follistatin-like 3 (FSTL3)

-0.353

0.02042

Transforming growth factor-beta-induced protein ig-h3 (TGFBI)

0.322

0.0036

Complement and immune response

Serpin peptidase inhibitor, clade G, member 1 (SERPING1)

0.551

0.01216

Complement C2 (C2)

0.333

0.00215

Complement factor H-related protein 5 (CFHL5)

0.294

6.72E-05

Complement factor B (BF)

0.271

1.06E-06

Pantetheinase (VNN1)

0.564

0.00079

Leucine-rich alpha-2-glycoprotein (LRG1)

0.539

0.00031

Neutrophil defensin 1 (DEFA1)

0.303

0.00683

Mannose-binding protein C (MBL2)

-0.300

0.00094

TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

-3.863

0.00762

Lactotransferrin (LTF) [69]

0.285

0.04264

Trefoil factor 3 (TFF3)

1.936

0.00019

Vessel morphogenesis

Autotaxin (ENPP2)

0.581

0.00395

Vasorin (SLITL2)

-0.383

0.01997

Transgelin 2 (TAGLN2)

-0.542

0.01725

Endothelial differentiation G-protein coupled receptor 3 (EDG3)

-2.998

0.00033

Cardiomyopathy associated protein 5 (CMYA5)

-4.1374

0.01562

Other

Angiotensinogen (AGT) [15,16]

1.148

7.16E-10

Cathepsin S (CTSS)

0.588

0.04665

Galectin-3-binding protein (LGALS3BP)

0.416

0.00214

Galectin 1 (LGALS1)

0.305

0.02924

E3 ubiquitin-protein ligase UBR1 (UBR1)

-0.422

0.00511

Tropomyosin alpha-4 chain (TPM4)

-1.258

0.0269

DNA helicase B (HELB)

-1.862

0.02157

Putative Polycomb group protein ASXL1 (ASXL1)

-2.658

0.02290

Protein CREG2 (CREG2)

Protein RIC1 homolog (KIAA1432)

-4.153

0.00155

Protein FAM59B (FAM59B)

-2.755

0.00119

KH homology domain-containing protein 1 (C6orf148)

-3.060

0.00116

Alpha-1B-glycoprotein (A1BG)

0.331

1.82E-06

Disks large homolog 2 (DLG2)

1.749

0.04913

Proteins with prior associations with ET are indicated with numbered references.

Katayama et al. Genome Medicine 2009 1:47   doi:10.1186/gm47