Research
Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
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* Corresponding author: Samir Hanash shanash@fhcrc.org
- † Equal contributors
1 Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
2 Laboratory of Core Technology, Eisai Co. Ltd, 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan
3 Department of Pediatrics, University of Michigan, Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA
4 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
5 Women's Health Initiative Branch, National Heart, Lung, and Blood Institute, Rockledge Dr., Bethesda, MD 20892, USA
6 Division of Endocrinology, Ohio State University, Dodd Dr., Columbus, OH 43210, USA
7 AstraZeneca LP, Concord Pike, Wilmington, DE 29850, USA
8 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, W. Carson Street, Torrance, CA 90502, USA
9 Brigham and Women's Hospital, Harvard Medical School, Boylston Street, Boston, MA 02215, USA
Genome Medicine 2009, 1:47 doi:10.1186/gm47
Published: 29 April 2009Additional files
Additional data file 1:
Ratios (1 year CEE/baseline) of gene-level weighted proteins for each IPAS (log2scale), number of events identified for each unique gene and their P-values.
Format: XLS Size: 348KB Download file
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Additional data file 2:
Weighted gene-level proteins quantified in two or more IPAS experiments with significant ratio 1 year ET/baseline (P < 0.05).
Format: XLS Size: 91KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional data file 3:
Proteins deregulated after 1 year ET with log-ratios >1.20 or <1/1.20.
Format: XLS Size: 61KB Download file
This file can be viewed with: Microsoft Excel Viewer