Figure 1.

Scope of the uncharacterized diversity within the HRV supergroup: 428 classic and novel HRV A (red), B (blue) and C (green) species sequences were aligned using Muscle within Geneious Pro v4.6.1. The circular neighbor-joining tree (Tamura-Nei model; 100 bootstraps with consensus support shown at the nodes where space permitted) was produced using Geneious Tree Builder and rooted using CVA-21 (pink). Only sequences included in the report by Palmenberg et al. [20] are labeled (multiples of the same strain are identified using the first two characters of the GenBank accession code or 'ATCC' to identify their origin as per reference [20]). Putatively novel strains and their variants are represented with a terminal gray circle. The subgenomic fragment spanned 266 nucleotides of the 1A (VP4)/1B (VP2) junction. CVA, coxsackievirus A; HEV, human enterovirus; PV, poliovirus.