Genome Medicine | Volume 1 Issue 4

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		Volume 1 Issue 4
		Comment
		Commentary Does genomic risk information motivate people to change their behavior? Nora B Henrikson, Deborah Bowen, Wylie Burke Genome Medicine 2009, 1:37 (2 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary If genetic risk information is to have any benefit on health, it needs to prompt individuals to pursue risk-reduction behaviors, yet early evidence suggests that genetic risk may not be an effective motivator of behavior change.
		Commentary New strategies and emerging technologies for massively parallel sequencing: applications in medical research Elaine R Mardis Genome Medicine 2009, 1:40 (17 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The impact of next-generation sequencing on medical research is dramatically increasing, although there are challenges that must be overcome to fully translate this technology into routine clinical practice.
		Commentary Genome-wide association studies in pharmacogenomics: untapped potential for translation Idris Guessous, Marta Gwinn, Muin J Khoury Genome Medicine 2009, 1:46 (28 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The integration of genome-wide association studies within the design of pharmacogenomics trials is currently underexploited but holds promise for accelerating the transfer of gene discoveries into clinical practice.
		Musings Musings on genome medicine: gene therapy David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:38 (3 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Despite slow progress and many barriers, the gene therapy may now be poised to move forward rapidly though the promises of site-specific gene correction using modified nucleases and the conversion of corrected somatic cells to functioning hematopoietic stem cells.
		Opinion Genomic disorders ten years on James R Lupski Genome Medicine 2009, 1:42 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary James R Lupski reviews the last decade of research into genomic disorders, from the original discoveries to their current position as one of the hottest fields of the post-genomic era.
		Review
		Minireview *Overexpression of MACC1* leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer** Lisa A Boardman Genome Medicine 2009, 1:36 (2 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary MACC1, a newly discovered gene that regulates the hepatocyte growth factor/receptor signaling cascade, may prove valuable for determining risk for colorectal cancer and as a target for its treatment.
		Minireview Human rhinoviruses: coming in from the cold Katherine E Arden, Ian M Mackay Genome Medicine 2009, 1:44 (28 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The sequencing of the genomes of all human rhinovirus (HRV) serotypes opens the road to comprehensive HRV characterization and offers valuable information for phylogenetic analysis and the development of novel therapeutics.
		Review Dissecting complex traits: recent advances in hypertension genomics Kevin M O'Shaughnessy Genome Medicine 2009, 1:43 (28 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome-wide scans have revealed novel susceptibility loci for essential hypertension and are being used to look for alleles that predict individual response to antihypertensive drugs, opening the way for personalized therapy for hypertensive patients.
		Report
		Meeting report New insights into genomic variation in health and disease Lauren A Weiss Genome Medicine 2009, 1:41 (22 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Genomic Disorders conference on Genomic Variation in Health and Disease, Hinxton, UK, 9–11 March, 2009.
		Meeting report Perspectives in stem cell proteomics Javier Muñoz, Albert JR Heck Genome Medicine 2009, 1:45 (28 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A brief report on the Perspectives in Stem Cell Proteomics Conference, Hinxton, UK, 22-23 March, 2009.
		Research
		Research A kernel-based integration of genome-wide data for clinical decision support Anneleen Daemen, Olivier Gevaert, Fabian Ojeda, Annelies Debucquoy, Johan AK Suykens, Christine Sempoux, Jean-Pascal Machiels, Karin Haustermans, Bart De Moor Genome Medicine 2009, 1:39 (3 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A kernel-based supervised classification algorithm allows the integration of genome-wide data from different sources and improves the prediction of clinical outcomes from cancer data sets.
		Research Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings Hiroyuki Katayama, Sophie Paczesny, Ross Prentice, Aaron Aragaki, Vitor M Faca, Sharon J Pitteri, Qing Zhang, Hong Wang, Melissa Silva, Jacob Kennedy, Jacques Rossouw, Rebecca Jackson, Judith Hsia, Rowan Chlebowski, JoAnn Manson, Samir Hanash Genome Medicine 2009, 1:47 (29 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first large-scale proteomic analysis of samples from the Women's Health Initiative reveals that estrogen replacement therapy affects at least 10% of the serum proteome, particularly proteins involved in processes related to cardiovascular disease and osteoporosis.

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