Table 1

Summary of loci associated with variation in adult BMI in two large GWASs

Odds ratio (95% CI) of obesity in adults

Chromosome

Genes

GIANT

deCODE

Relevant tissue expression and/or function

1p31

NEGR1

1.05 (1.01-1.11)

1.07 (1.02-1.12)

Adipose

1q25

SEC16B, RASAL2

1.11 (1.05-1.18)

Liver

2

TMEM18

1.19 (1.11-1.26)

1.20 (1.13-1.27)

3

ETV5, SFRS10, DGKG

1.11 (1.05-1.17)

4

GNPDA2

1.12 (1.07-1.17)

Adipose

6p21

NCR3, AIF1, BAT2

1.07 (1.02-1.12)

Hypothalamus; NCR3 also adipose

11p14

BDNF, LGR4, LIN7C

1.12 (1.06-1.19)

BDNF: hypothalamus; humans with BDNF deletion are obese, and knockdown in mouse hypothalamus leads to obesity

1.11 (1.05-1.16)

11p11

MTCH2

1.03 (0.98-1.08)

Adipose, hypothalamus and liver

12

FAIM2, BCDIN3D

1.14 (1.09-1.19)

Adipose, hypothalamus and liver

16p11

SH2B1, ATP2A1

1.11 (1.06-1.17)

1.08 (1.03-1.13)

SH2B1: adipose and hypothalamus; null mice are obese

16q12

FTO, RPGRIP1L

1.25 (1.19-1.31)

1.27 (1.21-1.32)

FTO: adipose and hypothalamus

1.16 (1.10-1.21)

18q21

MC4R

1.15 (1.08-1.21)

1.12 (1.06-1.17)

Hypothalamus; associated with obesity in humans, and MC4R deficient mice are obese

19

KCTD15, CHST8

1.04 (0.98-1.10)

1.10 (1.04-1.15)

Adipose and hypothalamus

Gene name abbreviations: AIF1, allograft inflammatory factor 1; ATP2A1, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; BAT2, HLA-B associated transcript 2; BCDIN3D, BCDIN3 domain containing; BDNF, brain-derived neurotrophic factor; CHST8, carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; DGKG, diacylglycerol kinase, gamma 90 kDa; ETV5, ets variant 5; FAIM2, Fas apoptotic inhibitory molecule 2; FTO, fat mass and obesity associated; GNPDA2, glucosamine-6-phosphate deaminase 2; KCTD15, potassium channel tetramerisation domain containing 15; LGR4, leucine-rich repeat-containing G protein-coupled receptor 4; LIN7C, in-7 homolog C; MC4R, melanocortin 4 receptor; MTCH2, mitochondrial carrier homolog 2; NCR3, natural cytotoxicity triggering receptor 3; NEGR1, neuronal growth regulator 1; RASAL2, RAS protein activator like 2; RPGRIP1L, RPGR-interacting protein 1-like protein; SEC16B, SEC16 homolog B (Saccharomyces cerevisiae); SFRS10, splicing factor, arginine/serine-rich 10; SH2B1, SH2B adaptor protein 2; TMEM18, transmembrane protein 18. CI, confidence interval.

Calton and Vaisse Genome Medicine 2009 1:31   doi:10.1186/gm31