Table 3

Effect estimates of 18 established susceptibility variants on type 2 diabetes risk in two studies

Odds ratio (95% confidence interval)*

Gene

Locus

GoDARTS study [11]

Rotterdam study [14]

TCF7L2

rs7903146

1.36 (1.24, 1.48)

1.31 (1.19, 1.44)

KCNJ11

rs5219

1.25 (1.15, 1.36)

1.03 (0.93, 1.13)

CDKN2A/2B

rs10811661

1.21 (1.08, 1.35)

1.10 (0.98, 1.24)

PPARG

rs1801282

1.21 (1.07, 1.36)

1.09 (0.95, 1.24)

ADAM30/NOTCH2

rs2641348^†

1.15 (1.01, 1.30)

1.01 (0.88, 1.17)

CDKN2A/2B

rs564398^‡

1.13 (1.04, 1.22)

1.04 (0.95, 1.14)

IGF2BP2

rs4402960

1.12 (1.03, 1.22)

1.11 (1.01, 1.22)

FTO

rs8050136

1.11 (1.02, 1.20)

1.09 (0.99, 1.19)

CDKAL1

rs10946398^§

1.11 (1.02, 1.21)

1.11 (1.02, 1.22)

SLC30A8

rs13266634

1.10 (1.01, 1.20)

1.13 (1.02, 1.24)

TSPAN8/LGR5

rs7961581^¶

1.09 (1.00, 1.19)

1.09 (0.99, 1.20)

CDC123

rs12779790^¥

1.10 (0.99, 1.21)

0.95 (0.84, 1.06)

WFS1

rs10010131**

1.07 (0.99, 1.16)

1.12 (1.05, 1.27)

TCF2

rs757210^††

1.07 (0.99, 1.16)

0.93 (0.85, 1.02)

ADAMTS9

rs4607103^‡‡

1.05 (0.96, 1.16)

1.14 (1.03, 1.28)

HHEX-IDE

rs1111875

1.02 (0.94, 1.11)

1.06 (0.97, 1.15)

THADA

rs7578597

1.04 (0.90, 1.19)

1.10 (0.96, 1.27)

JAZF1

rs864745^§S

1.00 (0.93, 1.09)

1.09 (1.00, 1.19)

*AUC (area under the receiver operating characteristic curve) was 0.60 for both studies. Values were obtained using logistic regression analyses. For several genes, the Rotterdam study [14] uses different single nucleotide polymorphisms from those listed: ^‡‡rs4411878, r2 = 0.95; ^¥rs11257622; r2 = 0.83; ^‡rs1412829, r2 = 0.97; ^§Srs1635852, r2 = 0.97; ^†rs1493694; ^¶rs1353362, r2 = 0.96; ^††rs4430796, r2 = 0.61; **rs10012946, r2 = 1.00; ^§rs7754840, r2 = 1.00. Statistically significant associations are presented in bold and r2 is a measure of linkage disequilibrium.

Janssens and van Duijn Genome Medicine 2009 1:20   doi:10.1186/gm20