Genome Medicine


Open Access Highly Access Research

Postmenopausal estrogen and progestin effects on the serum proteome

Sharon J Pitteri1, Samir M Hanash1, Aaron Aragaki1, Lynn M Amon1, Lin Chen1, Tina Busald Buson1, Sophie Paczesny1,2, Hiroyuki Katayama1,3, Hong Wang1, Melissa M Johnson1, Qing Zhang1, Martin McIntosh1, Pei Wang1, Charles Kooperberg1, Jacques E Rossouw4, Rebecca D Jackson5, JoAnn E Manson6, Judith Hsia7, Simin Liu8, Lisa Martin9 and Ross L Prentice1*

Author Affiliations

1 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA

2 Department of Pediatrics, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA

3 Biomarkers and Personalized Medicine Unit, Eisai Inc., 4 Corporate Drive, Andover, MA 01810, USA

4 WHI Project Office, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, USA

5 Division of Endocrinology, Ohio State University, 198 McCampbell, 1581 Dodd Drive, Columbus, OH 43210, USA

6 Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

7 Research and Development, AstraZeneca LP, 1971 Rockland Road, Wilmington, DE 19803, USA

8 Division of Public Health, Epidemiology & David Geffen School of Medicine, Department of Medicine, Box 951772, Los Angeles, CA 90095, USA

9 Department of Medicine, George Washington University, 2121 Eye St, NW; Washington, DC 20052, USA

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Genome Medicine 2009, 1:121 doi:10.1186/gm121

Published: 24 December 2009

Additional files

Additional file 1:

Table S1 shows year 1 to baseline log-transformed concentration ratios after estrogen plus progestin (E+P) or estrogen (E-Alone) exposure for all 378 quantified proteins.

Format: XLS Size: 98KB Download file

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Open Data