Genome Medicine

Search Genome Medicine for
Advanced Search
Genome Medicine
Tools
Open Access Highly Access Research

Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/ob mouse

Lee D Roberts1, David G Hassall2, Deborah A Winegar3, John N Haselden2, Andrew W Nicholls2 and Julian L Griffin1*

Author Affiliations

1 Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK

2 GlaxoSmithKline, Investigative Preclinical Toxicology, Park Road, Ware, SG12 0DP, UK

3 GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 277709-3398, USA


For all author emails, please log on.

Genome Medicine 2009, 1:115 doi:10.1186/gm115

Published: 7 December 2009

Additional files

Additional file 1:

Metabolites identified in the VIP/coefficients plots as significantly contributing to separation in the PCA and PLS-DA models built for the individual tissues. The control group was compared with the combined PPARδ agonist and PPARγ agonist treated groups. The R2 and Q2 values for the individual models are shown. Red up arrow indicates a detected increase in metabolite concentration. Down blue arrow indicates a detected decrease in metabolite concentration.

Format: PDF Size: 782KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Lipids identified in the VIP/coefficients plots as significantly contributing to separation in the PCA and PLS-DA models built for the UPLC-MS analysis of the organic metabolite fraction. The control group was compared with the PPARδ agonist and PPARγ agonist treated groups from liver and serum.

Format: PDF Size: 479KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data