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Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

Erik Larsson12, Peder Fredlund Fuchs3, Johan Heldin3, Irmeli Barkefors3, Cecilia Bondjers1, Guillem Genové4, Christelle Arrondel65, Pär Gerwins3, Christine Kurschat78, Bernhard Schermer78, Thomas Benzing78, Scott J Harvey5, Johan Kreuger3*¤ and Per Lindahl12*¤

Author Affiliations

1 Wallenberg Laboratory for Cardiovascular Research, Bruna Stråket 16, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden

2 Institute of Biomedicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden

3 Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, SE-751 23 Uppsala, Sweden

4 Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Lab of Vascular Biology, Karolinska Institutet, Scheeles väg, 2 A:3-P:4, SE-171 77 Stockholm, Sweden

5 Inserm U574, Hôpital Necker-Enfants Malades, Equipe Avenir Tour Lavoisier, 6e étage, 149 rue de Sèvres, 75015 Paris, France

6 Université Paris Descartes, Hôpital Necker-Enfants Malades, Equipe Avenir Tour Lavoisier, 6e étage, 149 rue de Sèvres, 75015 Paris, France

7 Department of Medicine and Centre for Molecular Medicine, University of Cologne, Kerpener Str. 62, 50937 Köln, Germany

8 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Kerpener Str. 62, 50937 Köln, Germany


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Genome Medicine 2009, 1:108 doi:10.1186/gm108

Published: 16 November 2009

Additional files

Additional data file 1:

Sequence information on predicted miR-145 target sites in the mouse Fli1 3' UTR.

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Additional data file 2:

Statistics on enrichment of miRNA in glomerulus and lungs.

Format: XLS Size: 175KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 3:

Expression levels of miR-145 in BJ-hTERT cells after transfection with miR-145 mimic or inhibitor, and of miR-145 and Fli1 in BJ-hTERT cells and endothelial cells, respectively.

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