Table 1

Examples of HLA associations with MS across the world among common alleles

HLA-DRB1 allele

Associated population

Approximate odds ratio

*01

Canada, Sweden, UK, US, [8,11,26,27]

0.6

*03 (17)

Canada, Sweden, UK, US, Italy, Sicily, Spain, Sardinia [8-11]

1.7

*04

Sardinia [35]

2.2

*07

Italy [7]

0.6

*08

Canada, UK, US, Italy, Sicily, Spain (15/08 genotype) [8,10,11]

6 (15/08 genotype)

*09

Japan [36]

0.4

*10

Italy, Canada [7,8,11]

2 (protective in Canadians)

*11

Canada, Malta [8,11,37]

0.7

*12^†

Canada [11]

0.9

*13

Sardinia, Israel [5,6]

2

*14

Canada, UK, US, Italy, Sicily, Spain [8,10,11]

0.3

*15

Near-universal

3

^†Based on a small number of observations. The allele frequency of HLA-DRB1*16 is too low to make any definitive conclusions.

Ramagopalan and Ebers Genome Medicine 2009 1:105   doi:10.1186/gm105