Genome Medicine | Volume 1 Issue 11

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		Volume 1 Issue 11
		Comment
		Commentary Multiple sclerosis: major histocompatibility complexity and antigen presentation Sreeram V Ramagopalan, George C Ebers Genome Medicine 2009, 1:105 (6 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Associations between susceptibility to multiple sclerosis and alleles of the major histocompatibility complex are probably more intricate than is currently thought and may prove to be crucial to understanding disease development.
		Commentary Data reporting standards: making the things we use better John Quackenbush Genome Medicine 2009, 1:111 (25 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary It is necessary to develop more effective methods for capturing the essence of genomic meta-data from individual studies and to enforce data-reporting standards, to ensure that the data have a life beyond their initial publication.
		Musings Musings on genome medicine: Crohn's disease David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:103 (5 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Inflammatory bowel diseases remain a challenge despite emerging large-scale genetic data and indications of bacterial influence whose application could lead to more long-term treatments.
		Review
		Minireview A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder Tatiana Roman, Luis A Rohde, Mara H Hutz Genome Medicine 2009, 1:107 (19 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome-wide studies suggest that attention-deficit/hyperactivity disorder could be caused, not by dopaminergic pathways as previously thought, but by genes related to more general brain functions.
		Review Tackling the methylome: recent methodological advances in genome-wide methylation profiling Marcos RH Estécio, Jean-Pierre J Issa Genome Medicine 2009, 1:106 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Technological advances in genome-wide methylation profiling are likely to lead to a better understanding of the importance of DNA methylation in cancer as a disease marker or a tumorigenesis driver.
		Review Sex chromosomes and genetic association studies David G Clayton Genome Medicine 2009, 1:110 (24 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The X chromosome presents problems for the efficient analysis of mixed-sex population genetic association studies due to the phenomenon of X inactivation and the assumption that allele frequencies differ between the sexes.
		Review Chronic obstructive pulmonary disease: towards pharmacogenetics Alice M Wood, See Ling Tan, Robert A Stockley Genome Medicine 2009, 1:112 (30 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knowledge of the pathophysiology and genetic risk factors for chronic obstructive pulmonary disease may help identify individuals who will respond differently to treatments.
		Review Secretome: clues into pathogen infection and clinical applications Shoba Ranganathan, Gagan Garg Genome Medicine 2009, 1:113 (30 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Secretory proteins play an important role in pathogenic infection and host-pathogen interactions, and their identification will lead to drug targets and diagnostic biomarkers.
		Report
		Meeting report Complex disease genetics: present and future translational applications Michael V Holmes, Sonia H Shah, Aspasia Angelakopoulou, Tauseef Khan, Daniel Swerdlow, Karoline Kuchenbaecker, Reecha Sofat, Tina Shah Genome Medicine 2009, 1:104 (5 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The success of genome-wide association studies and their future application were a principal theme at the "Genetics of Complex Diseases" meeting of the British Atherosclerosis Society in September 2009
		Meeting report Coming of age of personalized medicine: challenges ahead Pascal Borry Genome Medicine 2009, 1:109 (24 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent meeting in Banff, Canada on "The age of personal genomics" discussed ethical, legal and social controversies around the rapidly developing field of personalized genomics.
		Research
		Research Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1 Erik Larsson, Peder Fredlund Fuchs, Johan Heldin, Irmeli Barkefors, Cecilia Bondjers, Guillem Genové, Christelle Arrondel, Pär Gerwins, Christine Kurschat, Bernhard Schermer, Thomas Benzing, Scott J Harvey, Johan Kreuger, Per Lindahl Genome Medicine 2009, 1:108 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The microRNAs miR-145, miR-126, miR-24 and miR-23a are selectively expressed in microvascular fragments in vivo, and miR-145 blocks migration in response to growth factor gradients, offering a novel therapeutic candidate for vascular disease.

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