Genome Medicine | Volume 1 Issue 10

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	Volume 1 Issue 10
	Comment
	Commentary A new strategic phase for genomic medicine in UK health services Hilary Burton, Caroline F Wright, Ron Zimmern Genome Medicine 2009, 1:93 (12 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The field of genome medicine is at a crossroads due to the rapid development of new technologies, and a new health service strategy is urgently needed in the United Kingdom.
	Musings Musings on genome medicine: the slow but inexorable process of medical care reform in the United States David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:94 (12 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Attempts to improve the currently unsustainable healthcare system in the United States must be undertaken carefully to avoid weakening the US contribution to biomedical research and to genome medicine.
	Review
	Minireview Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies Durga Udayakumar, Hensin Tsao Genome Medicine 2009, 1:95 (27 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The ability to identify genetic variation associated with visible pigmentation traits and disease risk for cutaneous malignancy has provided a better understanding of the biology of disease and increased accuracy in risk prediction.
	Minireview Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism Kris Richardson, Jose M Ordovas Genome Medicine 2009, 1:96 (27 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Functional genomic and genome-wide association studies together provide a powerful way to identify candidate genes involved in cholesterol metabolism
	Minireview Rheumatoid arthritis: GWAS or TMI? Bruce N Cronstein Genome Medicine 2009, 1:98 (27 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The glut of newly identified genetic associations with smaller and smaller risks leads to findings that seem to be of increasingly marginal value, but these are still important for our understanding of disease.
	Minireview Insights into gliomagenesis: systems biology unravels key pathways Sandro J de Souza, Beatriz Stransky, Anamaria A Camargo Genome Medicine 2009, 1:101 (27 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systems biology approach has recently been used to characterize the genetic alterations that drive the genesis of gliomas, with implications for diagnosis and therapy.
	Review LINE dancing in the human genome: transposable elements and disease Victoria P Belancio, Prescott L Deininger, Astrid M Roy-Engel Genome Medicine 2009, 1:97 (27 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transposable elements generate a wide spectrum of genomic mutations, from point mutations to gross rearrangements with gain of genomic information, and interfere with normal gene processing and expression, thus significantly contributing to human disease.
	Review Synthetic lethality: a framework for the development of wiser cancer therapeutics William G Kaelin Genome Medicine 2009, 1:99 (27 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Screens for synthetic lethal interacting genes are helping to discover drugs that selectively kill cancer cells while leaving normal cells unscathed, as well as leading to wiser use of old drugs.
	Review Genetic overlap between autism, schizophrenia and bipolar disorder Liam S Carroll, Michael J Owen Genome Medicine 2009, 1:102 (30 October 2009) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Overlap between the loci that predispose to autism, schizophrenia and bipolar disorder suggests shared pathogenic mechanisms and challenges the view that these disorders are unrelated diagnostic entities.
	Research
	Research Next generation sequence analysis for mitochondrial disorders Valeria Vasta, Sarah B Ng, Emily H Turner, Jay Shendure, Si Houn Hahn Genome Medicine 2009, 1:100 (23 October 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Early and accurate diagnosis of mitochondrial disorders is promised by a cost-effective screening method which can rapidly detect mutations in several hundred candidate genes.