Genome Medicine


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Systems medicine: the future of medical genomics and healthcare

Charles Auffray*, Zhu Chen and Leroy Hood

Genome Med 2009, 1:2 doi:10.1186/gm2

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Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression

Rotem Ben-Hamo, Sol Efroni Genome Medicine 2011, 3:77 (28 November 2011)

Network-based analysis of gene expression data reveals a role for the p38 network and affiliated hsa-miR-9 in glioblastoma multiforme progression, implicating new biomarkers for predicting survival.

Research article   Open Access Highly Accessed

Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Francisco Azuaje, Yvan Devaux, Daniel R Wagner BMC Systems Biology 2010, 4:60 (12 May 2010)

Correspondence   Open Access

Bridging the gap between systems biology and medicine

Gilles Clermont, Charles Auffray, Yves Moreau, David M Rocke, Daniel Dalevi, Devdatt Dubhashi, Dana R Marshall, Peter Raasch, Frank Dehne, Paolo Provero, Jesper Tegner, Bruce J Aronow, Michael A Langston, Mikael Benson Genome Medicine 2009, 1:88 (29 September 2009)

The translation of data generated by systems biology approaches into the clinic generates a series of unique questions and challenges, and should be driven by the collaboration of clinical, experimental, and computational scientists.