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		Volume 1 Issue 1
		Comment
		Commentary Translating genomics into the clinic: moving to the post-Mendelian world Mildred K Cho Genome Medicine 2009, 1:7 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The prospects for genome medicine are exciting, but genomic analyses will only translate into medical practice once the validity of the diagnostic and predictive tools derived from genomic research is assured.
		Commentary The twin questions of personalized medicine: who are you and whom do you most resemble? Isaac S Kohane Genome Medicine 2009, 1:4 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Individualized medicine requires an understanding of who the patient is and of the subpopulation that they most resemble in the context of the decisions at hand.
		Commentary Two cheers for GINA? Amy L McGuire, Mary Majumder Genome Medicine 2009, 1:6 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The 2008 US Genetic Information Nondiscrimination Act (GINA) may alleviate public fear about genetic discrimination and facilitate genetic testing and participation in genetic research, but its limitations must not be overlooked.
		Editorial Genome Medicine: the future of medicine Melissa L Norton Genome Medicine 2009, 1:1 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In these exciting and fast-moving times, Genome Medicine launches with the aim of publishing outstanding post-genomic medical research and providing analysis of issues surrounding genomic medicine, as genomic and post-genomic research revolutionizes clinical practice.
		Musings Musings on genome medicine: genome wide association studies David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:3 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The great promise of genome-wide association studies (GWAS) must be balanced with the fact that many such studies are underpowered or not reproducible, and that for some diseases they provide little new information.
		Review
		Minireview *Variants in the ATM* gene and breast cancer susceptibility** Roger L Milne Genome Medicine 2009, 1:12 (22 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carriers of rare mutations in the ataxia-telangiectasia-related ATM gene have a two-fold higher risk of breast cancer, but studies of more common variants in the gene are less conclusive.
		Minireview Searching for the true genetic vulnerability for schizophrenia Lynn E DeLisi Genome Medicine 2009, 1:14 (23 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Three recent studies report rare copy-number variations associated with schizophrenia, although the results have yet to be validated by family studies.
		Review Systems medicine: the future of medical genomics and healthcare Charles Auffray, Zhu Chen, Leroy Hood Genome Medicine 2009, 1:2 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Systems approaches to medicine will transform the way drugs are developed and will enable medicine to become predictive, personalized, preventive and participatory.
		Review How close is the bench to the bedside? Metabolic profiling in cancer research Que N Van, Timothy D Veenstra Genome Medicine 2009, 1:5 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolic profiling using mass spectrometry and nuclear magnetic resonance spectroscopy offers promise for discovering novel cancer biomarkers, although its clinical applicability is a challenge.
		Review Pharmacogenomics of anticoagulants: steps toward personal dosage Ann K Daly Genome Medicine 2009, 1:10 (21 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic variation is increasingly recognized to be an important determinant of warfarin and other coumarin anticoagulant dose requirements for an effective and safe response.
		Review Systems pharmacology and genome medicine: a future perspective Aislyn D Wist, Seth I Berger, Ravi Iyengar Genome Medicine 2009, 1:11 (22 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome medicine forms the base on which systems pharmacology can develop, and the interface of the two fields will enable drug discovery for individualized medicine.
		Report
		Meeting report ASHG 2008 Annual Meeting: from enormous cohorts to individual genomes Lars Feuk Genome Medicine 2009, 1:9 (21 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of The 58th Annual Meeting of the American Society for Human Genetics (ASHG), Philadelphia, Pennsylvania, USA, 11-15 November, 2008.
		Meeting report A small step closer to the Holy Grail of DNA vaccines: undisputed clinical benefit in humans Lars Frelin, Matti Sällberg Genome Medicine 2009, 1:15 (23 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the DNA Vaccines 2008 meeting, Las Vegas, Nevada, USA, 9-11 December 2008.
		Correspondence
		Correspondence Race and ancestry in biomedical research: exploring the challenges Timothy Caulfield, Stephanie M Fullerton, Sarah E Ali-Khan, Laura Arbour, Esteban G Burchard, Richard S Cooper, Billie-Jo Hardy, Simrat Harry, Robyn Hyde-Lay, Jonathan Kahn, Rick Kittles, Barbara A Koenig, Sandra SJ Lee, Michael Malinowski, Vardit Ravitsky, Pamela Sankar, Stephen W Scherer, Béatrice Séguin, Darren Shickle, Guilherme Suarez-Kurtz, Abdallah S Daar Genome Medicine 2009, 1:8 (21 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An interdisciplinary workshop explores the controversies around the use of race in biomedical research and highlights challenges for an accurate representation of race not only in clinical trials but also by the lay press.
		Correspondence The Human Gene Mutation Database: 2008 update Peter D Stenson, Matthew Mort, Edward V Ball, Katy Howells, Andrew D Phillips, Nick ST Thomas, David N Cooper Genome Medicine 2009, 1:13 (22 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Human Gene Mutation Database (HGMD) contains over 80,000 germ-line mutations associated with human inherited diseases and has proven a valuable tool for researchers and physicians as well as commercial customers and genetic counsellors.

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		Volume 1 Issue 1
		Comment
		Commentary Translating genomics into the clinic: moving to the post-Mendelian world Mildred K Cho Genome Medicine 2009, 1:7 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The prospects for genome medicine are exciting, but genomic analyses will only translate into medical practice once the validity of the diagnostic and predictive tools derived from genomic research is assured.
		Commentary The twin questions of personalized medicine: who are you and whom do you most resemble? Isaac S Kohane Genome Medicine 2009, 1:4 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Individualized medicine requires an understanding of who the patient is and of the subpopulation that they most resemble in the context of the decisions at hand.
		Commentary Two cheers for GINA? Amy L McGuire, Mary Majumder Genome Medicine 2009, 1:6 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The 2008 US Genetic Information Nondiscrimination Act (GINA) may alleviate public fear about genetic discrimination and facilitate genetic testing and participation in genetic research, but its limitations must not be overlooked.
		Editorial Genome Medicine: the future of medicine Melissa L Norton Genome Medicine 2009, 1:1 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In these exciting and fast-moving times, Genome Medicine launches with the aim of publishing outstanding post-genomic medical research and providing analysis of issues surrounding genomic medicine, as genomic and post-genomic research revolutionizes clinical practice.
		Musings Musings on genome medicine: genome wide association studies David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:3 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The great promise of genome-wide association studies (GWAS) must be balanced with the fact that many such studies are underpowered or not reproducible, and that for some diseases they provide little new information.
		Review
		Minireview *Variants in the ATM* gene and breast cancer susceptibility** Roger L Milne Genome Medicine 2009, 1:12 (22 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carriers of rare mutations in the ataxia-telangiectasia-related ATM gene have a two-fold higher risk of breast cancer, but studies of more common variants in the gene are less conclusive.
		Minireview Searching for the true genetic vulnerability for schizophrenia Lynn E DeLisi Genome Medicine 2009, 1:14 (23 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Three recent studies report rare copy-number variations associated with schizophrenia, although the results have yet to be validated by family studies.
		Review Systems medicine: the future of medical genomics and healthcare Charles Auffray, Zhu Chen, Leroy Hood Genome Medicine 2009, 1:2 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Systems approaches to medicine will transform the way drugs are developed and will enable medicine to become predictive, personalized, preventive and participatory.
		Review How close is the bench to the bedside? Metabolic profiling in cancer research Que N Van, Timothy D Veenstra Genome Medicine 2009, 1:5 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolic profiling using mass spectrometry and nuclear magnetic resonance spectroscopy offers promise for discovering novel cancer biomarkers, although its clinical applicability is a challenge.
		Review Pharmacogenomics of anticoagulants: steps toward personal dosage Ann K Daly Genome Medicine 2009, 1:10 (21 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic variation is increasingly recognized to be an important determinant of warfarin and other coumarin anticoagulant dose requirements for an effective and safe response.
		Review Systems pharmacology and genome medicine: a future perspective Aislyn D Wist, Seth I Berger, Ravi Iyengar Genome Medicine 2009, 1:11 (22 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome medicine forms the base on which systems pharmacology can develop, and the interface of the two fields will enable drug discovery for individualized medicine.
		Report
		Meeting report ASHG 2008 Annual Meeting: from enormous cohorts to individual genomes Lars Feuk Genome Medicine 2009, 1:9 (21 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of The 58th Annual Meeting of the American Society for Human Genetics (ASHG), Philadelphia, Pennsylvania, USA, 11-15 November, 2008.
		Meeting report A small step closer to the Holy Grail of DNA vaccines: undisputed clinical benefit in humans Lars Frelin, Matti Sällberg Genome Medicine 2009, 1:15 (23 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the DNA Vaccines 2008 meeting, Las Vegas, Nevada, USA, 9-11 December 2008.
		Correspondence
		Correspondence Race and ancestry in biomedical research: exploring the challenges Timothy Caulfield, Stephanie M Fullerton, Sarah E Ali-Khan, Laura Arbour, Esteban G Burchard, Richard S Cooper, Billie-Jo Hardy, Simrat Harry, Robyn Hyde-Lay, Jonathan Kahn, Rick Kittles, Barbara A Koenig, Sandra SJ Lee, Michael Malinowski, Vardit Ravitsky, Pamela Sankar, Stephen W Scherer, Béatrice Séguin, Darren Shickle, Guilherme Suarez-Kurtz, Abdallah S Daar Genome Medicine 2009, 1:8 (21 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An interdisciplinary workshop explores the controversies around the use of race in biomedical research and highlights challenges for an accurate representation of race not only in clinical trials but also by the lay press.
		Correspondence The Human Gene Mutation Database: 2008 update Peter D Stenson, Matthew Mort, Edward V Ball, Katy Howells, Andrew D Phillips, Nick ST Thomas, David N Cooper Genome Medicine 2009, 1:13 (22 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Human Gene Mutation Database (HGMD) contains over 80,000 germ-line mutations associated with human inherited diseases and has proven a valuable tool for researchers and physicians as well as commercial customers and genetic counsellors.

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