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		Opinion From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms Marion Martin, Zdenko Herceg Genome Medicine 2012, 4:8 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Marion Martin and Zdenko Herceg discuss how cross-talk between inflammation and epigenetic mechanisms might be involved in the development of liver cancer.
		Research highlight Drug transporter regulation in tumors by DNA methylation Oliver Zolk, Martin F Fromm Genome Medicine 2012, 4:10 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oliver Zolk and Martin Fromm highlight a recent observation that uptake transporters for anticancer drugs are epigenetically regulated in hepatocellular carcinoma.
		Research highlight Improving bioinformatic pipelines for exome variant calling Hanlee P Ji Genome Medicine 2012, 4:7 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hanlee Ji discusses the Atlas2 suite, a new set of tools for calling variants in exome sequencing data that is faster and easier to use than comparable tools and could thus be useful in diagnostics.
		Meeting report A year of great leaps in genome research Jingde Zhu Genome Medicine 2012, 4:4 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jingde Zhu presents the recent progress made and highlights of the Beijing Genomics Institute's 6th International Conference on Genomics (ICG-VI), held in Shenzhen, China.
		Editorial Looking back at genomic medicine in 2011 Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2012, 4:9 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by our Section Editors provides their highlights of the past year and hints at likely future developments in genomic medicine.
		Review Emerging patterns of genetic overlap across autoimmune disorders Corinne Richard-Miceli, Lindsey A Criswell Genome Medicine 2012, 4:6 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lindsey Criswell and Corinne Richard-Miceli review risk loci that are shared among autoimmune disorders and how this information might help to explain common disease mechanisms.
		Meeting report The long journey of stem cell therapeutics Sarah Crawford Genome Medicine 2012, 4:5 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sarah Crawford presents the highlights and roadblocks of therapeutic applications from the Euroepistem 2011 meeting on 'Epigenomic Programming and Stem Cells for Drug Discovery'.
		Research highlight Recycling side-effects into clinical markers for drug repositioning Miquel Duran-Frigola, Patrick Aloy Genome Medicine 2012, 4:3 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miquel Duran-Frigola and Patrick Aloy discuss a new computational approach to systematically exploring novel potential applications of already marketed drugs in distinct therapeutic areas.
		Research The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls Marcus Ronninger, Yongjing Guo, Klementy Shchetynsky, Andrew Hill, Mohsen Khademi, Tomas Olsson, Padmalatha S Reddy, Maria Seddighzadeh, James D Clark, Lih-Ling Lin, Margot O'Toole, Leonid Padyukov Genome Medicine 2012, 4:2 (20 January 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Genotyping and phenotyping of cells from rheumatoid arthritis patients and healthy controls reveals different patterns of expression for the protein tyrosine phosphatase non-receptor 22 gene.
		Research Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia Matej Oresic, Tuulikki Seppanen-Laakso, Daqiang Sun, Jing Tang, Sebastian Therman, Rachael Viehman, Ulla Mustonen, Theo GM van Erp, Tuulia Hyotylainen, Paul Thompson, Arthur W Toga, Matti O Huttunen, Jaana Suvisaari, Jaakko Kaprio, Jouko Lonnqvist, Tyrone D Cannon Genome Medicine 2012, 4:1 (18 January 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Lipidomic, imaging and neurocognitive analysis of twin pairs reveals lipid biomarkers linked to decreased cognitive speed and potentially increased susceptibility to infection in schizophrenia.
		Research highlight Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future trials Ram N Ganapathi, Ronald M Bukowski Genome Medicine 2011, 3:79 (30 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ganapathi and Bukowski discuss the advances and pitfalls of a recent study of single nucleotide polymorphisms to predict the activity or toxicity of sunitinib for clear cell renal cell carcinoma.
		Review Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model Corey S Martin, Akemi Moriyama, Leonard I Zon Genome Medicine 2011, 3:83 (29 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Martin, Moriyama and Zon review the advantages of zebrafish for studying early development of blood cells and highlight recent discoveries using this model that show clinical promise.
		Review Health care providers and direct-to-consumer access and advertising of genetic testing in the United States Melanie F Myers Genome Medicine 2011, 3:81 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Melanie Myers reviews the impact of advertising and selling of genetic testing direct to consumers on health care providers and asks whether providers are ready to deal with this issue.
		Research highlight Metabonomics adds a new dimension to fragile X syndrome Inge Heulens, Sien Braat, R Frank Kooy Genome Medicine 2011, 3:80 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Kooy and colleagues highlight a recent study that provides new insights into the mechanisms underlying Fragile X syndrome through the metabolomics analysis of mouse models.
		Meeting report Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing Mia Wadelius, Ana Alfirevic Genome Medicine 2011, 3:78 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mia Wadelius and Ana Alfirevic present highlights from the Cold Spring Harbor and the Wellcome Trust 2011 meeting on 'Pharmacogenomics and Personalized Medicine'.
		Research DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma Elke Schaeffeler, Claus Hellerbrand, Anne T Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M Zanger, Hermann Koepsell, Matthias Schwab Genome Medicine 2011, 3:82 (23 December 2011) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary First evidence that decreased protein expression of the transporter SLC22A1 in hepatocellular carcinoma correlates with increased methylation of individual CpG sites.
		Review Pharmacogenetics in type 2 diabetes: potential implications for clinical practice Chunmei Huang, Jose C Florez Genome Medicine 2011, 3:76 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chunmei Huang and Jose Florez review recent insights into type 2 diabetes that are emerging from pharmacogenetic and pharmacogenomic studies, and discuss the potential for clinical translation.
		Review Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine Jonghwan Kim, Stuart H Orkin Genome Medicine 2011, 3:75 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jonghwan Kim and Stuart Orkin review recent genome-scale and systems approaches to understand the regulatory networks that are common to embryonic stem (ES) cells and cancer.
		Research Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression Rotem Ben-Hamo, Sol Efroni Genome Medicine 2011, 3:77 (28 November 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Network-based analysis of gene expression data reveals a role for the p38 network and affiliated hsa-miR-9 in glioblastoma multiforme progression, implicating new biomarkers for predicting survival.
		Research highlight Circulating microRNAs as biomarkers - True Blood? Nathalie Schöler, Christian Langer, Florian Kuchenbauer Genome Medicine 2011, 3:72 (23 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Florian Kuchenbauer and colleagues highlight a recent study revealing that blood-borne microRNA expression data or the "miRNome" could be a powerful tool for the blood-based diagnosis of disease.
		Research highlight RNA-Seq and find: entering the RNA deep field Adam Roberts, Lior Pachter Genome Medicine 2011, 3:74 (22 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lior Pachter and Adam Roberts discuss the advantages of a new method, RNA CaptureSeq, for the detection of low-abundance transcripts potentially important for disease, within the RNA "deep field".
		Meeting report Using DNA sequencers as stethoscopes Melissa Gymrek, Yaniv Erlich Genome Medicine 2011, 3:73 (21 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gymrek and Erlich discuss the success stories and challenges of translating genomic research into the clinic highlighted at the Cold Spring Harbor Laboratory meeting on 'Personal Genomes'.
		Meeting report Epigenomic insights into common disease Kate Revill, Benjamin Tycko Genome Medicine 2011, 3:71 (15 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Revill and Tycko report on the Wellcome Trust Scientific Conference on 'Epigenomics of Common Diseases', highlighting this fast-moving field with particular emphasis on genome-wide studies.
		Meeting report Genomics of common diseases: approaching the tipping point Alan F Wright Genome Medicine 2011, 3:70 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alan Wright reports highlights of the Wellcome Trust Scientific Conference 'The Genomics of Common Diseases 2011', emphasizing the limitations of GWAS and promise of new technologies.
		Review Transcriptomic analysis of pluripotent stem cells: insights into health and disease Jia-Chi Yeo, Huck-Hui Ng Genome Medicine 2011, 3:68 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jia-Chi Yeo and Huck-Hui Ng review recent progress in understanding the transcriptional networks of pluripotent stem cells, and discuss how this knowledge has impacted translational medicine.

	All
		Opinion From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms Marion Martin, Zdenko Herceg Genome Medicine 2012, 4:8 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Marion Martin and Zdenko Herceg discuss how cross-talk between inflammation and epigenetic mechanisms might be involved in the development of liver cancer.
		Research highlight Drug transporter regulation in tumors by DNA methylation Oliver Zolk, Martin F Fromm Genome Medicine 2012, 4:10 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oliver Zolk and Martin Fromm highlight a recent observation that uptake transporters for anticancer drugs are epigenetically regulated in hepatocellular carcinoma.
		Research highlight Improving bioinformatic pipelines for exome variant calling Hanlee P Ji Genome Medicine 2012, 4:7 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hanlee Ji discusses the Atlas2 suite, a new set of tools for calling variants in exome sequencing data that is faster and easier to use than comparable tools and could thus be useful in diagnostics.
		Meeting report A year of great leaps in genome research Jingde Zhu Genome Medicine 2012, 4:4 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jingde Zhu presents the recent progress made and highlights of the Beijing Genomics Institute's 6th International Conference on Genomics (ICG-VI), held in Shenzhen, China.
		Editorial Looking back at genomic medicine in 2011 Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2012, 4:9 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by our Section Editors provides their highlights of the past year and hints at likely future developments in genomic medicine.
		Review Emerging patterns of genetic overlap across autoimmune disorders Corinne Richard-Miceli, Lindsey A Criswell Genome Medicine 2012, 4:6 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lindsey Criswell and Corinne Richard-Miceli review risk loci that are shared among autoimmune disorders and how this information might help to explain common disease mechanisms.
		Meeting report The long journey of stem cell therapeutics Sarah Crawford Genome Medicine 2012, 4:5 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sarah Crawford presents the highlights and roadblocks of therapeutic applications from the Euroepistem 2011 meeting on 'Epigenomic Programming and Stem Cells for Drug Discovery'.
		Research highlight Recycling side-effects into clinical markers for drug repositioning Miquel Duran-Frigola, Patrick Aloy Genome Medicine 2012, 4:3 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miquel Duran-Frigola and Patrick Aloy discuss a new computational approach to systematically exploring novel potential applications of already marketed drugs in distinct therapeutic areas.
		Research The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls Marcus Ronninger, Yongjing Guo, Klementy Shchetynsky, Andrew Hill, Mohsen Khademi, Tomas Olsson, Padmalatha S Reddy, Maria Seddighzadeh, James D Clark, Lih-Ling Lin, Margot O'Toole, Leonid Padyukov Genome Medicine 2012, 4:2 (20 January 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Genotyping and phenotyping of cells from rheumatoid arthritis patients and healthy controls reveals different patterns of expression for the protein tyrosine phosphatase non-receptor 22 gene.
		Research Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia Matej Oresic, Tuulikki Seppanen-Laakso, Daqiang Sun, Jing Tang, Sebastian Therman, Rachael Viehman, Ulla Mustonen, Theo GM van Erp, Tuulia Hyotylainen, Paul Thompson, Arthur W Toga, Matti O Huttunen, Jaana Suvisaari, Jaakko Kaprio, Jouko Lonnqvist, Tyrone D Cannon Genome Medicine 2012, 4:1 (18 January 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Lipidomic, imaging and neurocognitive analysis of twin pairs reveals lipid biomarkers linked to decreased cognitive speed and potentially increased susceptibility to infection in schizophrenia.
		Research highlight Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future trials Ram N Ganapathi, Ronald M Bukowski Genome Medicine 2011, 3:79 (30 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ganapathi and Bukowski discuss the advances and pitfalls of a recent study of single nucleotide polymorphisms to predict the activity or toxicity of sunitinib for clear cell renal cell carcinoma.
		Review Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model Corey S Martin, Akemi Moriyama, Leonard I Zon Genome Medicine 2011, 3:83 (29 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Martin, Moriyama and Zon review the advantages of zebrafish for studying early development of blood cells and highlight recent discoveries using this model that show clinical promise.
		Review Health care providers and direct-to-consumer access and advertising of genetic testing in the United States Melanie F Myers Genome Medicine 2011, 3:81 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Melanie Myers reviews the impact of advertising and selling of genetic testing direct to consumers on health care providers and asks whether providers are ready to deal with this issue.
		Research highlight Metabonomics adds a new dimension to fragile X syndrome Inge Heulens, Sien Braat, R Frank Kooy Genome Medicine 2011, 3:80 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Kooy and colleagues highlight a recent study that provides new insights into the mechanisms underlying Fragile X syndrome through the metabolomics analysis of mouse models.
		Meeting report Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing Mia Wadelius, Ana Alfirevic Genome Medicine 2011, 3:78 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mia Wadelius and Ana Alfirevic present highlights from the Cold Spring Harbor and the Wellcome Trust 2011 meeting on 'Pharmacogenomics and Personalized Medicine'.
		Research DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma Elke Schaeffeler, Claus Hellerbrand, Anne T Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M Zanger, Hermann Koepsell, Matthias Schwab Genome Medicine 2011, 3:82 (23 December 2011) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary First evidence that decreased protein expression of the transporter SLC22A1 in hepatocellular carcinoma correlates with increased methylation of individual CpG sites.
		Review Pharmacogenetics in type 2 diabetes: potential implications for clinical practice Chunmei Huang, Jose C Florez Genome Medicine 2011, 3:76 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chunmei Huang and Jose Florez review recent insights into type 2 diabetes that are emerging from pharmacogenetic and pharmacogenomic studies, and discuss the potential for clinical translation.
		Review Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine Jonghwan Kim, Stuart H Orkin Genome Medicine 2011, 3:75 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jonghwan Kim and Stuart Orkin review recent genome-scale and systems approaches to understand the regulatory networks that are common to embryonic stem (ES) cells and cancer.
		Research Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression Rotem Ben-Hamo, Sol Efroni Genome Medicine 2011, 3:77 (28 November 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Network-based analysis of gene expression data reveals a role for the p38 network and affiliated hsa-miR-9 in glioblastoma multiforme progression, implicating new biomarkers for predicting survival.
		Research highlight Circulating microRNAs as biomarkers - True Blood? Nathalie Schöler, Christian Langer, Florian Kuchenbauer Genome Medicine 2011, 3:72 (23 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Florian Kuchenbauer and colleagues highlight a recent study revealing that blood-borne microRNA expression data or the "miRNome" could be a powerful tool for the blood-based diagnosis of disease.
		Research highlight RNA-Seq and find: entering the RNA deep field Adam Roberts, Lior Pachter Genome Medicine 2011, 3:74 (22 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lior Pachter and Adam Roberts discuss the advantages of a new method, RNA CaptureSeq, for the detection of low-abundance transcripts potentially important for disease, within the RNA "deep field".
		Meeting report Using DNA sequencers as stethoscopes Melissa Gymrek, Yaniv Erlich Genome Medicine 2011, 3:73 (21 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gymrek and Erlich discuss the success stories and challenges of translating genomic research into the clinic highlighted at the Cold Spring Harbor Laboratory meeting on 'Personal Genomes'.
		Meeting report Epigenomic insights into common disease Kate Revill, Benjamin Tycko Genome Medicine 2011, 3:71 (15 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Revill and Tycko report on the Wellcome Trust Scientific Conference on 'Epigenomics of Common Diseases', highlighting this fast-moving field with particular emphasis on genome-wide studies.
		Meeting report Genomics of common diseases: approaching the tipping point Alan F Wright Genome Medicine 2011, 3:70 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alan Wright reports highlights of the Wellcome Trust Scientific Conference 'The Genomics of Common Diseases 2011', emphasizing the limitations of GWAS and promise of new technologies.
		Review Transcriptomic analysis of pluripotent stem cells: insights into health and disease Jia-Chi Yeo, Huck-Hui Ng Genome Medicine 2011, 3:68 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jia-Chi Yeo and Huck-Hui Ng review recent progress in understanding the transcriptional networks of pluripotent stem cells, and discuss how this knowledge has impacted translational medicine.