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		Editorial Predictive, preventive, personalized and participatory medicine: back to the future Charles Auffray, Dominique Charron, Leroy Hood Genome Medicine 2010, 2:57 (26 August 2010) Abstract \| Full text \| PDF \| Editor’s summary The pioneering work of Jean Dausset on the human leukocyte antigen system provides lessons that should be applied to systems medicine.
		Minireview Recent insights into the role of NF-kappaB in ovarian carcinogenesis Ayesha B Alvero Genome Medicine 2010, 2:56 (25 August 2010) Abstract \| Full text \| PDF \| Editor’s summary NF-κB plays a role in the initiation and progression of ovarian cancer and represents a potential target for the development of novel therapeutics for this type of cancer.
		Review Genomic imprinting in diabetes Braxton D Mitchell, Toni I Pollin Genome Medicine 2010, 2:55 (23 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic imprinting is known to have a role in 6q24-related transient neonatal diabetes, and recent research has also revealed parent of origin effects in type I and II diabetes mellitus.
		Minireview Environmental exposures and mutational patterns of cancer genomes Gerd P Pfeifer Genome Medicine 2010, 2:54 (16 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Whole-genome sequences of cancers reveal the different kinds of mutation caused by environmental carcinogens.
		Correspondence Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Charles Swanton, James MG Larkin, Marco Gerlinger, Aron C Eklund, Michael Howell, Gordon Stamp, Julian Downward, Martin Gore, P Andrew Futreal, Bernard Escudier, Fabrice Andre, Laurence Albiges, Benoit Beuselinck, Stephane Oudard, Jens Hoffmann, Balazs Gyorffy, Chris Torrance, Karen A Boehme, Hansjuergen Volkmer, Luisella Toschi, Barbara Nicke, Marlene Beck, Zoltan Szallasi Genome Medicine 2010, 2:53 (11 August 2010) Abstract \| Provisional PDF \| PubMed
		Commentary Shared pathways to infectious disease susceptibility? Chiea C Khor, Martin L Hibberd Genome Medicine 2010, 2:52 (10 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genomic research so far suggests that host susceptibility to different pathogens is controlled by discrete genes and pathways, but as technology develops it may unravel shared mechanisms across multiple pathogen groups.
		Correspondence Translational bioinformatics in the cloud: an affordable alternative Joel T Dudley, Yannick Pouliot, Rong Chen, Alexander A Morgan, Atul J Butte Genome Medicine 2010, 2:51 (6 August 2010) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Cloud-based analysis offers a valid alternative both in terms of performance and cost to local computational clusters for the integration and analysis of large-scale genomic datasets relevant for translational research.
		Review Prenatal diagnosis of fetal aneuploidies: post-genomic developments Sinuhe Hahn, Laird G Jackson, Bernhard G Zimmermann Genome Medicine 2010, 2:50 (5 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Non-invasive prenatal diagnosis of fetal aneuploidies may soon become possible with new genomic and proteomic technologies.
		Commentary Whole proteomes as internal standards in quantitative proteomics Shao-En Ong Genome Medicine 2010, 2:49 (30 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pooling several proteomes labeled with stable isotopes yields an internal standard that can greatly increase the accuracy of quantitative proteomics.
		Commentary Piecing together the problems in diagnosing low-level chromosomal mosaicism Caroline Robberecht, Jean-Pierre Fryns, Joris Robert Vermeesch Genome Medicine 2010, 2:47 (29 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low-level somatic chromosomal mosaicism can cause disease but is not easy to detect; genomic technologies are improving understanding and opening up new possibilities for diagnosis.
		Review Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers? Fredrik Wiklund Genome Medicine 2010, 2:45 (29 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary While genome-wide association studies have revealed genetic variants associated with prostate cancer, there is a need for further research into genetic factors able to discriminate between indolent and fatal forms of the disease in order to improve clinical management.
		Review Functional genomics and rheumatoid arthritis: where have we been and where should we go? James N Jarvis, Mark Barton Frank Genome Medicine 2010, 2:44 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gene expression profiling studies have enabled the development of signatures for patient classification and prediction of response to therapy in rheumatoid arthritis, and ongoing research into the transcriptome will likely bring further insight into our understanding of the disease.
		Commentary Models of the human metabolic network: aiming to reconcile metabolomics and genomics Philip W Kuchel Genome Medicine 2010, 2:46 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mainstream view of metabolism is being challenged, and creating a computer model of the metabolic network requires the development of new metabolite analysis techniques before it can become a reality.
		Research Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling Ross L Prentice, Sophie Paczesny, Aaron Aragaki, Lynn M Amon, Lin Chen, Sharon J Pitteri, Martin McIntosh, Pei Wang, Tina Buson Busald, Judith Hsia, Rebecca D Jackson, Jacques E Rossouw, JoAnn E Manson, Karen Johnson, Charles Eaton, Samir M Hanash Genome Medicine 2010, 2:48 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In-depth proteome analysis of samples from postmenopausal women identifies the level of beta-2 microglobulin and insulin-like growth factor binding protein as biomarkers for risk of coronary heart disease and stroke respectively.
		Review The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection John E Heckels, Jeannette N Williams Genome Medicine 2010, 2:43 (22 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sequencing of genomes and availability of the corresponding protein databases, combined with sensitive proteomic techniques, have opened up exciting new avenues in meningococcal vaccine research.
		Commentary Ethical issues raised by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice Arthur L Beaudet Genome Medicine 2010, 2:42 (17 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tests for single nucleotide polymorphisms and copy number variations generate differing ethical issues, but offering either test direct to consumers without guidance and interpretation from a physician or counselor raises further concerns.
		Review Clinical proteomics of myeloid leukemia Sigrun M Hjelle, Rakel B Forthun, Ingvild Haaland, H�kon Reikvam, Gry Sj�holt, �ystein Bruserud, Bj�rn T Gjertsen Genome Medicine 2010, 2:41 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research into the leukemic cell proteomes should lead to the development of molecular diagnostic tools and the identification of novel biomarkers for the prediction of response to therapy in myeloid leukemias, opening new avenues for personalized medicine.
		Minireview Serotonin transporter polymorphisms and panic disorder Johannes Schumacher, J�rgen Deckert Genome Medicine 2010, 2:40 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The identification of polymorphisms of the serotonin transporter gene SLC6A4 as risk variants for panic disorder could pave the way for a better understanding of the pathophysiology of anxiety disorders and the development of prevention strategies.
		Musings So what have data standards ever done for us? The view from metabolomics Julian L Griffin, Christoph Steinbeck Genome Medicine 2010, 2:38 (24 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolomic data standardization is lagging behind some other research fields, but there would be great benefits if all metabolomic data were submitted to a central repository in a standard format.
		Review Genomic insights into early-onset obesity H�l�ne Choquet, David Meyre Genome Medicine 2010, 2:36 (23 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genomic research is improving our understanding of the genetic factors that play a role in the development of early-onset obesity and may pave the way for personalized preventive strategies and therapy.
		Minireview ABO blood group and other genetic variants associated with pancreatic cancer Anne Lennon, Alison P Klein, Michael Goggins Genome Medicine 2010, 2:39 (22 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent genome-wide association studies of pancreatic cancer have resurrected hypotheses of associations with ABO blood group.
		Research High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure Mun-Kit Choy, Mehregan Movassagh, Lee Siggens, Ana Vujic, Martin Goddard, Ana S�nchez, Neil Perkins, Nichola Figg, Martin Bennett, Jason Carroll, Roger Foo Genome Medicine 2010, 2:37 (14 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A cooperative transcription factor complex involving p53, NF-kappa-B and STAT3 is responsible for the transcriptional regulation of miRNA-21, a microRNA relevant for the pathology of heart failure.
		Review Novel genes for QTc interval. How much heritability is explained, and how much is left to find? Yalda Jamshidi, Ilja M Nolte, Timothy D Spector, Harold Snieder Genome Medicine 2010, 2:35 (27 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary QTc interval is a complex trait with prognostic relevance for cardiovascular mortality, and about 10% of the heritability of this trait can be identified in a genetic risk model examining significant single nucleotide polymorphisms.
		Review Retinitis pigmentosa and allied conditions today: a paradigm of translational research Carmen Ayuso, Jose M Millan Genome Medicine 2010, 2:34 (27 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knowledge of genes and pathways involved in photoreceptor degeneration underlying retinitis pigmentosa is the first step in implementing correct clinical management, and possible prevention or therapy.
		Minireview The role of complex genomic alterations in neuroblastoma risk estimation Matthias Fischer, Frank Berthold Genome Medicine 2010, 2:31 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Global genomic profiles could help define the prognosis of neuroblastoma patients.

		Editorial Predictive, preventive, personalized and participatory medicine: back to the future Charles Auffray, Dominique Charron, Leroy Hood Genome Medicine 2010, 2:57 (26 August 2010) Abstract \| Full text \| PDF \| Editor’s summary The pioneering work of Jean Dausset on the human leukocyte antigen system provides lessons that should be applied to systems medicine.
		Minireview Recent insights into the role of NF-kappaB in ovarian carcinogenesis Ayesha B Alvero Genome Medicine 2010, 2:56 (25 August 2010) Abstract \| Full text \| PDF \| Editor’s summary NF-κB plays a role in the initiation and progression of ovarian cancer and represents a potential target for the development of novel therapeutics for this type of cancer.
		Review Genomic imprinting in diabetes Braxton D Mitchell, Toni I Pollin Genome Medicine 2010, 2:55 (23 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic imprinting is known to have a role in 6q24-related transient neonatal diabetes, and recent research has also revealed parent of origin effects in type I and II diabetes mellitus.
		Minireview Environmental exposures and mutational patterns of cancer genomes Gerd P Pfeifer Genome Medicine 2010, 2:54 (16 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Whole-genome sequences of cancers reveal the different kinds of mutation caused by environmental carcinogens.
		Correspondence Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Charles Swanton, James MG Larkin, Marco Gerlinger, Aron C Eklund, Michael Howell, Gordon Stamp, Julian Downward, Martin Gore, P Andrew Futreal, Bernard Escudier, Fabrice Andre, Laurence Albiges, Benoit Beuselinck, Stephane Oudard, Jens Hoffmann, Balazs Gyorffy, Chris Torrance, Karen A Boehme, Hansjuergen Volkmer, Luisella Toschi, Barbara Nicke, Marlene Beck, Zoltan Szallasi Genome Medicine 2010, 2:53 (11 August 2010) Abstract \| Provisional PDF \| PubMed
		Commentary Shared pathways to infectious disease susceptibility? Chiea C Khor, Martin L Hibberd Genome Medicine 2010, 2:52 (10 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genomic research so far suggests that host susceptibility to different pathogens is controlled by discrete genes and pathways, but as technology develops it may unravel shared mechanisms across multiple pathogen groups.
		Correspondence Translational bioinformatics in the cloud: an affordable alternative Joel T Dudley, Yannick Pouliot, Rong Chen, Alexander A Morgan, Atul J Butte Genome Medicine 2010, 2:51 (6 August 2010) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Cloud-based analysis offers a valid alternative both in terms of performance and cost to local computational clusters for the integration and analysis of large-scale genomic datasets relevant for translational research.
		Review Prenatal diagnosis of fetal aneuploidies: post-genomic developments Sinuhe Hahn, Laird G Jackson, Bernhard G Zimmermann Genome Medicine 2010, 2:50 (5 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Non-invasive prenatal diagnosis of fetal aneuploidies may soon become possible with new genomic and proteomic technologies.
		Commentary Whole proteomes as internal standards in quantitative proteomics Shao-En Ong Genome Medicine 2010, 2:49 (30 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pooling several proteomes labeled with stable isotopes yields an internal standard that can greatly increase the accuracy of quantitative proteomics.
		Commentary Piecing together the problems in diagnosing low-level chromosomal mosaicism Caroline Robberecht, Jean-Pierre Fryns, Joris Robert Vermeesch Genome Medicine 2010, 2:47 (29 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low-level somatic chromosomal mosaicism can cause disease but is not easy to detect; genomic technologies are improving understanding and opening up new possibilities for diagnosis.
		Review Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers? Fredrik Wiklund Genome Medicine 2010, 2:45 (29 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary While genome-wide association studies have revealed genetic variants associated with prostate cancer, there is a need for further research into genetic factors able to discriminate between indolent and fatal forms of the disease in order to improve clinical management.
		Review Functional genomics and rheumatoid arthritis: where have we been and where should we go? James N Jarvis, Mark Barton Frank Genome Medicine 2010, 2:44 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gene expression profiling studies have enabled the development of signatures for patient classification and prediction of response to therapy in rheumatoid arthritis, and ongoing research into the transcriptome will likely bring further insight into our understanding of the disease.
		Commentary Models of the human metabolic network: aiming to reconcile metabolomics and genomics Philip W Kuchel Genome Medicine 2010, 2:46 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mainstream view of metabolism is being challenged, and creating a computer model of the metabolic network requires the development of new metabolite analysis techniques before it can become a reality.
		Research Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling Ross L Prentice, Sophie Paczesny, Aaron Aragaki, Lynn M Amon, Lin Chen, Sharon J Pitteri, Martin McIntosh, Pei Wang, Tina Buson Busald, Judith Hsia, Rebecca D Jackson, Jacques E Rossouw, JoAnn E Manson, Karen Johnson, Charles Eaton, Samir M Hanash Genome Medicine 2010, 2:48 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In-depth proteome analysis of samples from postmenopausal women identifies the level of beta-2 microglobulin and insulin-like growth factor binding protein as biomarkers for risk of coronary heart disease and stroke respectively.
		Review The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection John E Heckels, Jeannette N Williams Genome Medicine 2010, 2:43 (22 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sequencing of genomes and availability of the corresponding protein databases, combined with sensitive proteomic techniques, have opened up exciting new avenues in meningococcal vaccine research.
		Commentary Ethical issues raised by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice Arthur L Beaudet Genome Medicine 2010, 2:42 (17 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tests for single nucleotide polymorphisms and copy number variations generate differing ethical issues, but offering either test direct to consumers without guidance and interpretation from a physician or counselor raises further concerns.
		Review Clinical proteomics of myeloid leukemia Sigrun M Hjelle, Rakel B Forthun, Ingvild Haaland, H�kon Reikvam, Gry Sj�holt, �ystein Bruserud, Bj�rn T Gjertsen Genome Medicine 2010, 2:41 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research into the leukemic cell proteomes should lead to the development of molecular diagnostic tools and the identification of novel biomarkers for the prediction of response to therapy in myeloid leukemias, opening new avenues for personalized medicine.
		Minireview Serotonin transporter polymorphisms and panic disorder Johannes Schumacher, J�rgen Deckert Genome Medicine 2010, 2:40 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The identification of polymorphisms of the serotonin transporter gene SLC6A4 as risk variants for panic disorder could pave the way for a better understanding of the pathophysiology of anxiety disorders and the development of prevention strategies.
		Musings So what have data standards ever done for us? The view from metabolomics Julian L Griffin, Christoph Steinbeck Genome Medicine 2010, 2:38 (24 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolomic data standardization is lagging behind some other research fields, but there would be great benefits if all metabolomic data were submitted to a central repository in a standard format.
		Review Genomic insights into early-onset obesity H�l�ne Choquet, David Meyre Genome Medicine 2010, 2:36 (23 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genomic research is improving our understanding of the genetic factors that play a role in the development of early-onset obesity and may pave the way for personalized preventive strategies and therapy.
		Minireview ABO blood group and other genetic variants associated with pancreatic cancer Anne Lennon, Alison P Klein, Michael Goggins Genome Medicine 2010, 2:39 (22 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent genome-wide association studies of pancreatic cancer have resurrected hypotheses of associations with ABO blood group.
		Research High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure Mun-Kit Choy, Mehregan Movassagh, Lee Siggens, Ana Vujic, Martin Goddard, Ana S�nchez, Neil Perkins, Nichola Figg, Martin Bennett, Jason Carroll, Roger Foo Genome Medicine 2010, 2:37 (14 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A cooperative transcription factor complex involving p53, NF-kappa-B and STAT3 is responsible for the transcriptional regulation of miRNA-21, a microRNA relevant for the pathology of heart failure.
		Review Novel genes for QTc interval. How much heritability is explained, and how much is left to find? Yalda Jamshidi, Ilja M Nolte, Timothy D Spector, Harold Snieder Genome Medicine 2010, 2:35 (27 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary QTc interval is a complex trait with prognostic relevance for cardiovascular mortality, and about 10% of the heritability of this trait can be identified in a genetic risk model examining significant single nucleotide polymorphisms.
		Review Retinitis pigmentosa and allied conditions today: a paradigm of translational research Carmen Ayuso, Jose M Millan Genome Medicine 2010, 2:34 (27 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knowledge of genes and pathways involved in photoreceptor degeneration underlying retinitis pigmentosa is the first step in implementing correct clinical management, and possible prevention or therapy.
		Minireview The role of complex genomic alterations in neuroblastoma risk estimation Matthias Fischer, Frank Berthold Genome Medicine 2010, 2:31 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Global genomic profiles could help define the prognosis of neuroblastoma patients.