Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.

Editor

  • Rebecca Furlong, PhD, Genome Medicine

Acting Editor

  • Louisa Flintoft, PhD, Genome Medicine

Articles

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  • Image attributed to: Part of Fig 1, showing methylation patterns of cancer genomes

    Pan-cancer patterns of DNA methylation

    Christoph Plass and colleagues review advances in methylome profiling across cancer types, and discuss how the detection of different methylation subgroups can inform our understanding of cancer development as well as clinical management.

    Genome Medicine 2014, 6:66
  • Image attributed to: Figure from Irizarry and colleagues

    Hypomethylated blocks are a feature of cancer

    A comprehensive genome-scale study of multiple solid tumors showed that hypomethylated blocks are a universal feature of common solid tumors and occur early in malignancy.

    Genome Medicine 2014, 6:61
  • Image attributed to: Phenotypic similarity network

    Insights from drug-disease phenotype similarity

    An analysis of phenotypic similarity between 4,869 human diseases and 1,667 drugs suggests possible contraindications and provides insight into mechanisms of disease and drug side effects.

    Genome Medicine 2014, 6:52
  • Image attributed to: Detail of Figure 5 from Deavidsen et al.

    Insights into muscle wasting in COPD

    A systems biology approach comparing muscle transcriptional profiles in the chronic cigarette smoke guinea pig model and COPD patients suggests the involvement of CXCL10 and CXCL9 in muscle wasting.

    Genome Medicine 2014, 6:59
  • Image attributed to: Part of fg1 form article

    Epigenetics of disease-discordant twins

    Tim Spector and colleagues review recent epigenetic studies of monozygotic twins with discordance for a variety of diseases including cancer, autoimmune disorders and neurological diseases.

    Genome Medicine 2014, 6:60
  • Image attributed to: Figure from DawnRank by Ma

    Finding personalized cancer drivers

    It is a challenge to assess whether rare and patient-specific mutations are cancer drivers. The algorithm DawnRank prioritizes altered genes on a single patient level.

    Genome Medicine 2014, 6:56
  • Image attributed to: Part of fig1 from article, showing one of the proposed formats

    Patient-friendly formats for genomic tests

    Susanne Haga and colleagues propose four options for the development of patient-friendly formats for genetic and genomic test reports to promote patients' understanding of their test results.

    Genome Medicine 2014, 6:58
  • Image attributed to: Detail of Figure 5 from Jeong et al.

    Systematic cancer drug target identification

    An integrated approach to predict and validate novel anti-cancer drug targets, with demonstration of strong anti-proliferative effects of predicted targets.

    Genome Medicine 2014, 6:57

Featured free review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.


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Beyond the Genome: Cancer Genomics 2014
Cancer Epigenomics
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  • Cancer epigenomics
    Edited by: Prof Stephan Beck
    Published: 22 May 2014
    Last updated: 27 June 2014

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  • PubMed Central
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ISSN: 1756-994X