Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD, BioMed Central


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  • Image attributed to: Detail of Figure 3_from Haider et al.

    Advances in pancreatic cancer prognostic

    A large retrospective meta-analysis on pancreatic ductal adenocarninoma gene expression studies reveals a 36-gene prognostic signature for patient stratification and overall survival.

    Genome Medicine 2014, 6:105
  • Image attributed to: Detail of Figure 4_from Malhotra et al.

    Mining biomarkers for Alzheimer's disease

    A gray zone approach combining text mining and context-specific modeling of molecular interactions underlying stages of Alzheimer's disease identifies potential biomarkers.

    Genome Medicine 2014, 6:97
  • Image attributed to: Crowd scene by Amy Mingo from Wikipedia commons

    The impact of personal genomics

    A description of the design and methods used in a collaboration between academia, 23andme and Pathway genomics to explore the effect of direct to consumer testing on participants.

    Genome Medicine 2014, 6:96
  • Image attributed to: Image supplied by Dan Knights

    Unravelling the genome-microbiome interaction in IBD

    The dissociation of genome-microbiome interactions uncovers a web of complex interacting factors influencing the inflammatory bowel disease microbiome.

    Genome Medicine 2014, 6:107
  • Image attributed to: From Fig 4 Liu et al.

    Feed forward loops for drug repurposing

    To improve the management of cystic fibrosis, a drug repurposing approach was used that incorporated transcription factor and miRNA information to generate feed forward loops and therapeutic suggestions.

    Genome Medicine 2014, 6:94
  • Image attributed to: Image from Fig 2 Pattini and colleagues

    Hypoxia network for APL

    An integrated network-based approach to understanding the specificity of the hypoxia response to acute promyelocytic leukemia uncovers a distinct network and involvement of EMT genes.

    Genome Medicine 2014, 6:84
  • Image attributed to: Bacteria on culture plate_from Flickr

    How is NGS changing clinical microbiology?

    Didier Raoult and colleagues discuss how advances in bacterial genome sequencing are guiding improved clinical diagnostic tools, better characterization of pathogens, and tracking of outbreaks.

    Genome Medicine 2014, 6:114
  • Image attributed to: Fig 2, showing approaches for detecting VH PPIs

    Virus-host interactomics and drug discovery

    Vincent Lotteau and colleagues review advances in interactomic approaches for viral infections, and discuss the implications for the development of host-oriented antiviral therapeutics.

    Genome Medicine 2014, 6:115

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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ISSN: 1756-994X