Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD, BioMed Central
Blood transcriptional profiling of patients with sepsis, including survivors and non-survivors, reveals survival is associated with a strong immune response and with missense variants in VPS9D1.
Massey and Read discuss the recent advances and remaining challenges in the field of bacterial GWAS and propose strategies to improve the validation and dissect mechanism.
Gardy and Tang discuss in light of a study by Mark Pallen and colleagues how genomic epidemiology can help track events within outbreaks and guide the design of targeted control strategies in real-time.
Whole blood expression profiling of patients with Kawasaki disease or bacterial and viral infections, reveals a unique innate immunity signature and identifies the IL1β pathway as a potential therapeutic target.
A tool for genome-wide visualization and analysis of mutations in Candida albicans, allowing interrogation of copy number variation,SNPs and loss of heterozygosity.
Lasken and McLean discuss recent technological advances that are allowing the analysis of bacteria at single-cell resolution and the potential future applications in infectious disease research.
A read-mapping based tool for fast and accurate detection of genes, alleles and multi-locus sequence types from whole genome sequences for common bacterial pathogens.
Whole genome sequencing of multi-drug resistant Acinetobacter baumannii in a prolonged hospital outbreak in Birmingham, UK, advises on control and prevention strategies.
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