Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD, Genome Medicine

Acting Editor

  • Louisa Flintoft, PhD, Genome Medicine


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  • Image attributed to: From Rico et al.

    Gene expression in patient-derived xenografts

    Transcriptomic analysis shows for the first time that patient-derived xenografts in mice are more closely related to primary tumors than cell lines are for pancreatic tumors.

    Genome Medicine 2014, 6:27
  • Image attributed to: Figure from article, showing mutation signature

    Mutation signatures of carcinogen exposure

    Steven Rozen and colleagues review advances in next-generation sequencing approaches for the detection of mutation signatures of carcinogen exposure, and discuss the implications for cancer prevention.

    Genome Medicine 2014, 6:24
  • Image attributed to: Detail of Figure 3_from McCarthy et al.

    What to consider for variant annotation?

    A quantitative analysis of the impact of choice of transcript dataset and software on variant annotation in the context of a whole genome sequencing study, reveals both variables have a substantial effect.

    Genome Medicine 2014, 6:26
  • Image attributed to: Detail of Figure 1_from Shin et al.

    Dissecting cause in cardiometabolic disease

    A novel statistical framework can assess the contribution of metabolites in mediating the association between two types of known disease risk factos, genetic variants and circulating lipid traits.

    Genome Medicine 2014, 6:25
  • Clinical translation of cancer genomics

    Elaine Mardis discusses the impact of NGS technologies in cancer, the remaining barriers to clinical translation, and new applications for early detection, patient monitoring and precision medicine.

    Genome Medicine 2014, 6:22
  • Image attributed to: White blood cell

    Correcting cell-type bias in EWAS

    Vardhman Rakyan and Robert Lowe discuss recent articles that use bioinformatics to address confounding by heterogenous cell types in epigenome-wide association studies.

    Genome Medicine 2014, 6:23
  • Image attributed to: Bridging the gap from iStock photos.

    Multiscale modelling for systems medicine

    Olaf Wolkenhauer and colleagues discuss the steps that need to be taken to enable integration of knowledge across multiple layers of organization — a crucial challenge for systems medicine.

    Genome Medicine 2014, 6:21
  • Image attributed to: Image from Roberts et al.

    Detecting KIR gene polymorphisms

    Killer-cell immunoglobulin-like receptors play roles in infection, transplantation and pregnancy, but genotyping is difficult. A new ddPCR approach could make haplotype definition routine.

    Genome Medicine 2014, 6:20

Featured free review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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  • Participatory Medicine
    Edited by: Leroy Hood, Dr Charles Auffray
    Published: 20 December 2013
    Last updated: 28 February 2014

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ISSN: 1756-994X