Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD,
A relationship between disease subtype in chronic lymphocytic leukemia and variation in gene expression suggests that variability has an effect on tumor adaptability and aggressiveness.
Timpson and Corbin discuss how a recent study looking at inactivating mutations in NPC1L1 provides insight into therapy with ezetimibe, used to reduce plasma cholesterol levels in coronary heart disease.
A novel method combining flow-sorting to separate tumor populations by ploidy with high-throughput sequencing shows promise to trace genome evolution in human cancer.
Disease-specific Bayesian models provide a robust, accurate and transparent framework to integrate multiple sources of evidence for the interpretation of novel variants from gene sequencing.
Comprehensive DNA methylome maps of human erythroblasts differentiated ex vivo from CD34+ progenitor cells purified from fetal liver or bone marrow reveal widespread dynamic changes during erythropoiesis.
Evaluation of patient-derived xenografts from rare and common cancers identifies it as a suitable discovery tool for cancer epigenomics.
A gray zone approach combining text mining and context-specific modeling of molecular interactions underlying stages of Alzheimer's disease identifies potential biomarkers.
A large retrospective meta-analysis on pancreatic ductal adenocarninoma gene expression studies reveals a 36-gene prognostic signature for patient stratification and overall survival.
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