Calculating genetic risk from multiple loci

The widely accepted unconstrained multiplicative model which combines genome wide association data for overall risk calculation is not realistic, while other models more compatible with the data are indistinguishable using currently available observed parameters.

Multiple microRNAs muscle in on diabetes

Muscle mRNA expression is invariant with respect to diabetes status, but coordinated changes in numerous microRNAs may control protein abundance and affect skeletal muscle insulin resistance, a critical component of the disease.

Ewings sarcoma: genomic clues when EWS/FLI1 fuse

Ewing's sarcoma family tumors express the fusion protein EWS/FLI1, modulation of which is a desirable therapeutic goal.

Hunting for hepatitis C pharmacogenetics

Recent advances in our understanding of the genetics of response to interferon treatment are intriguing, but further research is necessary before we can achieve a true cure for hepatitis C.

Speaking out about specific language impairment

Four genes involved in specific language impairment have now been identified, highlighting a variety of neural pathways which contribute to the disorder.

A new approach to primary biliary cirrhosis?

Association of primary biliary cirrhosis with many genetic variants has not greatly improved our understanding of the disease, but epigenomic and microRNA research may provide more answers.

Risks and benefits of the 1000 Genomes Project

Safeguarding against ethical and privacy concerns will help clinical research to benefit from the 1000 Genomes Project.

Improving complex disease risk prediction

Inclusion of phenotypic and genotypic information from close relatives in a genetic risk prediction model can lead to improved estimates of an individual’s disease risk.