Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD, Genome Medicine
- Louisa Flintoft, PhD, Genome Medicine
Transcriptomic analysis shows for the first time that patient-derived xenografts in mice are more closely related to primary tumors than cell lines are for pancreatic tumors.
Steven Rozen and colleagues review advances in next-generation sequencing approaches for the detection of mutation signatures of carcinogen exposure, and discuss the implications for cancer prevention.
A quantitative analysis of the impact of choice of transcript dataset and software on variant annotation in the context of a whole genome sequencing study, reveals both variables have a substantial effect.
A novel statistical framework can assess the contribution of metabolites in mediating the association between two types of known disease risk factos, genetic variants and circulating lipid traits.
Elaine Mardis discusses the impact of NGS technologies in cancer, the remaining barriers to clinical translation, and new applications for early detection, patient monitoring and precision medicine.
Vardhman Rakyan and Robert Lowe discuss recent articles that use bioinformatics to address confounding by heterogenous cell types in epigenome-wide association studies.
Olaf Wolkenhauer and colleagues discuss the steps that need to be taken to enable integration of knowledge across multiple layers of organization — a crucial challenge for systems medicine.
Killer-cell immunoglobulin-like receptors play roles in infection, transplantation and pregnancy, but genotyping is difficult. A new ddPCR approach could make haplotype definition routine.
Latest articles from Genome Biology
Genome Biology 2014, 15:R65
Genome Biology 2014, 15:304
Genome Biology 2014, 15:R64
Genome Biology 2014, 15:R63
From the blog
- 03 February 2014
- The face of medicine is changing – are we ready for the new era?