Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.

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  • Rebecca Furlong, PhD, BioMed Central

Articles

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  • Image attributed to: Detail of Figure 3_from Tsalik et al.

    Expressed variants and sepsis outcomes

    Blood transcriptional profiling of patients with sepsis, including survivors and non-survivors, reveals survival is associated with a strong immune response and with missense variants in VPS9D1.

    Genome Medicine 2014, 6:111
  • Image attributed to: Bacteria

    State-of-the-art and future of bacterial GWAS

    Massey and Read discuss the recent advances and remaining challenges in the field of bacterial GWAS and propose strategies to improve the validation and dissect mechanism.

    Genome Medicine 2014, 6:109
  • Image attributed to: Hospital bed_from wikipedia

    Genomic epidemiology for pathogen outbreaks

    Gardy and Tang discuss in light of a study by Mark Pallen and colleagues how genomic epidemiology can help track events within outbreaks and guide the design of targeted control strategies in real-time.

    Genome Medicine 2014, 6:104
  • Image attributed to: Detail of Figure 8_from Hoang et al.

    A transcriptional signature of Kawasaki disease

    Whole blood expression profiling of patients with Kawasaki disease or bacterial and viral infections, reveals a unique innate immunity signature and identifies the IL1β pathway as a potential therapeutic target.

    Genome Medicine 2014, 6:102
  • Image attributed to: From Berman and colleagues

    YMAP: yeast mapping analysis pipeline

    A tool for genome-wide visualization and analysis of mutations in Candida albicans, allowing interrogation of copy number variation,SNPs and loss of heterozygosity.

    Genome Medicine 2014, 6:100
  • Image attributed to: Vibrio vulnificus_by CDC/Janice Haney Carr via WikimediaCommons

    Single-cell genomics and infectious diseases

    Lasken and McLean discuss recent technological advances that are allowing the analysis of bacteria at single-cell resolution and the potential future applications in infectious disease research.

    Genome Medicine 2014, 6:108
  • Image attributed to: From Fig 7 Inouye et al.

    SRST2 for genomic surveillance

    A read-mapping based tool for fast and accurate detection of genes, alleles and multi-locus sequence types from whole genome sequences for common bacterial pathogens.

    Genome Medicine 2014, 6:90
  • Image attributed to: A. baumnanni from CDC. credit Janice Carr via wikimedia commons

    Outbreak control guided by genome sequencing

    Whole genome sequencing of multi-drug resistant Acinetobacter baumannii in a prolonged hospital outbreak in Birmingham, UK, advises on control and prevention strategies.

    Genome Medicine 2014, 6:70

Featured free review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.


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genomics to diseases mechanisms
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ISSN: 1756-994X