Medicine in the post-genomic era
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Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
**Data from May 2014.
- Rebecca Furlong, PhD, Genome Medicine
- Louisa Flintoft, PhD, Genome Medicine
Tim Spector and colleagues review recent epigenetic studies of monozygotic twins with discordance for a variety of diseases including cancer, autoimmune disorders and neurological diseases.
Susanne Haga and colleagues propose four options for the development of patient-friendly formats for genetic and genomic test reports to promote patients' understanding of their test results.
It is a challenge to assess whether rare and patient-specific mutations are cancer drivers. The algorithm DawnRank prioritizes altered genes on a single patient level.
An integrated approach to predict and validate novel anti-cancer drug targets, with demonstration of strong anti-proliferative effects of predicted targets.
Xu Tan and Steve Elledge discuss a new approach to finding new therapeutic routes for HIV therapy by screening for drug combinations that increase transcriptional noise to reactivate latent viruses.
The NIH requires investigators to submit de-identified genomic data to dbGaP. This study explores the feasibility of re-contact and finds a small proportion of participants oppose submitting data.
Barbara Bernhardt explains how advances in clinical genomics are changing the role of genetic counselors by necessitating the communication of increasing amounts of complex information.
Matthew Farrer and Michelle Lin review advances in genetic and genomic studies of sporadic, Mendelian and more complex forms of parkinsonism, implicating the involvement of specific molecular pathways.
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