Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD, BioMed Central
A large retrospective meta-analysis on pancreatic ductal adenocarninoma gene expression studies reveals a 36-gene prognostic signature for patient stratification and overall survival.
A gray zone approach combining text mining and context-specific modeling of molecular interactions underlying stages of Alzheimer's disease identifies potential biomarkers.
A description of the design and methods used in a collaboration between academia, 23andme and Pathway genomics to explore the effect of direct to consumer testing on participants.
The dissociation of genome-microbiome interactions uncovers a web of complex interacting factors influencing the inflammatory bowel disease microbiome.
To improve the management of cystic fibrosis, a drug repurposing approach was used that incorporated transcription factor and miRNA information to generate feed forward loops and therapeutic suggestions.
An integrated network-based approach to understanding the specificity of the hypoxia response to acute promyelocytic leukemia uncovers a distinct network and involvement of EMT genes.
Didier Raoult and colleagues discuss how advances in bacterial genome sequencing are guiding improved clinical diagnostic tools, better characterization of pathogens, and tracking of outbreaks.
Vincent Lotteau and colleagues review advances in interactomic approaches for viral infections, and discuss the implications for the development of host-oriented antiviral therapeutics.
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