Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.

Editor

  • Rebecca Furlong, PhD, Genome Medicine

Acting Editor

  • Louisa Flintoft, PhD, Genome Medicine

Articles

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  • Image attributed to: Authors' figure of a pie chart

    Informed consent in childhood cancer sequencing

    Consent for clinical tumor sequencing in children is more dependent on emotional aspects than race or ethnicity, while genomic privacy concerns are low.

    Genome Medicine 2014, 6:69
  • Image attributed to: Detail from Figure 1

    Cancer therapy leads from yeast conservation

    Screens in yeast can be used to identify conserved interactions with the mismatch repair pathway to provide new avenues for cancer therapy based on synthetic lethality.

    Genome Medicine 2014, 6:68
  • Image attributed to: Figures from manuscript by Montini and colleagues

    VISPA to identify viral integration sites

    A bioinformatics pipeline for automated identification and annotation of viral vector genomic integration sites for hematopoietic stem-cell-based gene therapy.

    Genome Medicine 2014, 6:67
  • Image attributed to: Simon Lovestone

    Blood biomarkers for Alzheimer's disease?

    Simon Lovestone discusses recent progress in the development of molecular biomarkers for the diagnosis and prognosis of Alzheimer’s disease.

    Genome Medicine 2014, 6:65
  • Image attributed to: Part of Fig 1, showing methylation patterns of cancer genomes

    Pan-cancer patterns of DNA methylation

    Christoph Plass and colleagues review advances in methylome profiling across cancer types, and discuss how the detection of different methylation subgroups can inform our understanding of cancer development as well as clinical management.

    Genome Medicine 2014, 6:66
  • Image attributed to: Image from Fang and Gough.

    ‘dnet’ cancer survival network

    Construction of a network of genes for which most of the mutations are significantly correlated with patient survival, irrespective of tumor type.

    Genome Medicine 2014, 6:64
  • Image attributed to: Figure from Irizarry and colleagues

    Hypomethylated blocks are a feature of cancer

    A comprehensive genome-scale study of multiple solid tumors showed that hypomethylated blocks are a universal feature of common solid tumors and occur early in malignancy.

    Genome Medicine 2014, 6:61
  • Image attributed to: Image depicting genetic mutation

    Next-generation carrier screening

    Thomas Prior discusses how next-generation sequencing is allowing a major expansion in carrier screening tests, and highlights the educational and counselling challenges.

    Genome Medicine 2014, 6:62

Featured free review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.


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Beyond the Genome: Cancer Genomics 2014
Cancer Epigenomics
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Article collections

  • Cancer epigenomics
    Edited by: Prof Stephan Beck
    Published: 22 May 2014
    Last updated: 30 August 2014

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ISSN: 1756-994X