Genome Medicine


Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods and software tools in all areas of medicine studied from a post-genomic perspective. The journal also provides review and comment on the latest advances in translational genomics and personalized medicine, and their implications for the clinical and ethical management of human health and disease.

Editor

  • Rebecca Furlong, PhD

Articles

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  • Metabolomic staging of colorectal cancer

    Serum metabolomic profiles change markedly with metastasis of colorectal cancer, a finding that will have clinical utility in enhancing staging accuracy and selecting the right treatment for patients.

    Genome Medicine 2012, 4:42
  • Image attributed to: manhattan plot from wikimedia

    Overcoming the limits of GWAS

    Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.

    Genome Medicine 2012, 4:34
  • Image attributed to: H-NMR plot from author figure

    A metabolomic understanding of PPARs

    Julian Griffin and colleagues review the role metabolomics has played in elucidating the roles of peroxisome proliferator-activated receptors in systemic metabolism regulation.

    Genome Medicine 2012, 4:32
  • Image attributed to: Metabolomics image produced by Genome Medicine

    Metabolomics: the final frontier?

    Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.

    Genome Medicine 2012, 4:40
  • Image attributed to: MRI scan from wikimedia

    Extending the human CSF metabolome

    A comprehensive and quantitative update of the human cerebrospinal fluid metabolome database is provided by multi-platform analysis of multiple CSF samples and an extensive literature review.

    Genome Medicine 2012, 4:38
  • Image attributed to: Heatmap from author figure 3

    Breast cancer metabolomics

    Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.

    Genome Medicine 2012, 4:37
  • Image attributed to: Image of a mouse from wikimedia

    Metabolic changes linked with TETA treatment

    Metabolomic analysis of serum samples in a streptozotocin-induced diabetes rat model reveals metabolic pathways affected by treatment with oral triethylenetetramine, a potential therapy for diabetes.

    Genome Medicine 2012, 4:35
  • Image attributed to: Histology image authors figure

    Combining histology and metabolomics

    A clinical workflow for concurrent metabolite extraction and histological analysis of intact tumor biopsies allows augmentation of histopathological diagnosis with quantitative biochemical measures.

    Genome Medicine 2012, 4:33
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Gene regulatory network inference in ovarian cancer
Metabolomics of disease special issue
Beyond the Genome 2012
Epigenetic changes in cervical cancer
Monthly issues alert

Latest issue

Genome Medicine Volume 4 Issue 4

The complete issue of Genome Medicine Volume 4 Issue 4 is now available.

Beyond the Genome 2012

The 3rd annual Beyond the Genome conference takes place in Harvard Medical School, Boston from 27-29 September 2012.

Keynote speakers announced:
Richard Gibbs, Baylor College of Medicine, USA
Stuart Schreiber, Broad Institute of Harvard and MIT, USA

Register and submit your abstract

Featured free review

Fusing metabolomics and genomics


figure

Robinette, Holmes, Nicholson and Dumas review data-fusion techniques using metabonomics, metabolomics and genomics, and the implications for functional genomics, metagenomics and disease modeling.


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Quotes

Muin Khoury

The long term success of genomic medicine depends on establishing a strong evidence base for its validity and utility using clinical and population translational studies. Genome Medicine can be a forum for publishing original research and systematic reviews beyond bench to bedside.


Dr Muin Khoury,
Section Editor, Genome Medicine
Office of Public Health Genomics, CDC
Epidemiology and Genetics Research Program, NCI

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Indexed by

  • CAS
  • PubMed
  • PubMed Central
  • Scopus

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ISSN: 1756-994X