Medicine in the post-genomic era

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Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.

**Data from May 2014.

Editor

  • Rebecca Furlong, PhD, Genome Medicine

Acting Editor

  • Louisa Flintoft, PhD, Genome Medicine

Articles

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  • Image attributed to: screenshot from dbGaP homepage

    Re-contacting participants for dbGaP inclusion

    The NIH requires investigators to submit de-identified genomic data to dbGaP. This study explores the  feasibility of re-contact and finds a small proportion of participants oppose submitting data.

    Genome Medicine 2014, 6:54
  • Image attributed to: Barbara Bernhardt

    The changing role of genetic counselors

    Barbara Bernhardt explains how advances in clinical genomics are changing the role of genetic counselors by necessitating the communication of increasing amounts of complex information.

    Genome Medicine 2014, 6:49
  • Image attributed to: Figure 1 from article showing affected molecular pathways

    Parkinson's disease genomics

    Matthew Farrer and Michelle Lin review advances in genetic and genomic studies of sporadic, Mendelian and more complex forms of parkinsonism, implicating the involvement of specific molecular pathways.

    Genome Medicine 2014, 6:48
  • Image attributed to: Doctors with computer

    Improving genomics education for physicians

    Michael F. Murray discusses the increasingly urgent need to improve genomics education for physicians and some exciting new projects that are aimed at meeting this need.

    Genome Medicine 2014, 6:45
  • Image attributed to: Fig 2 from Anjum et al.

    Predicting breast cancer

    A blood-based DNA methylation signature derived from BRCA1 carriers is able to predict non-hereditary breast cancer risk and death years in advance of diagnosis.

    Genome Medicine 2014, 6:47
  • Image attributed to: Fig 3 from Riva et al.

    DOTS-Finder for cancer genome drivers

    A computational tool to predict driver genes and classify them as tumor suppressors or oncogenes. It is able to analyse mutation profiling data from any tumor type and uses somatic mutation data.

    Genome Medicine 2014, 6:44
  • Image attributed to: Pieces of a jigsaw

    The importance of epistasis in complex disease

    Trudy Mackay and Jason Moore argue that epistasis has been wrongly ignored in the quest to understand and predict complex human disease and explore how this situation can be changed.

    Genome Medicine 2014, 6:42
  • Image attributed to: Illustration of nucleosome, from Wikimedia Commons

    Integrating cancer epigenomics and genomics

    In this Comment, Christoph Bock argues that cancer epigenomics and genomics projects should work more closely together, and he advocates the creation of an International Cancer Epigenome Consortium.

    Genome Medicine 2014, 6:41

Featured free review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.


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Beyond the Genome: Cancer Genomics 2014
Data sharing in genomics
Cancer Epigenomics
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Article collections

  • Cancer epigenomics
    Edited by: Prof Stephan Beck
    Published: 22 May 2014
    Last updated: 27 June 2014

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ISSN: 1756-994X