Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods and software tools in all areas of medicine studied from a post-genomic perspective. The journal also provides review and comment on the latest advances in translational genomics and personalized medicine, and their implications for the clinical and ethical management of human health and disease.
Articles
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Genome Medicine 2013, 5:47Molecular heterogeneity of CLL
Catherine Wu and Dan Landau review genomic studies of chronic lymphocytic leukemia, which have revealed genetic and epigenetic heterogeneity, and mutations associated with poor prognosis.
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Genome Medicine 2013, 5:46Limitations overcome in target enrichment
Stephan Zuchner and Toumy Guettouche discuss the advantages of a recently published approach for target sequence enrichment to be used in clinical diagnosis and highlight potential new applications.
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Genome Medicine 2013, 5:44Genome-wide studies of osteoporosis
Hong-Wen Deng and colleagues review genome-wide approaches for identifying risk factors for osteoporosis, including genome-wide association, gene expression profiling and proteomic studies.
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Genome Medicine 2013, 5:50cLPP: a new method for exome target capture
An approach to enrich for regions of interest in the DNA, using complementary long padlock probes, shows improved accuracy and target coverage and potentially lower cost than previous methods.
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Genome Medicine 2013, 5:49Sequencing of HPV+ head and neck cancer
Next-generation sequencing of head and neck squamous cell carcinoma uncovers genetic alterations in HPV+ and HPV- tumors, suggesting a causal role for HPV in this cancer.
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Genome Medicine 2013, 5:42Stalking cancer in the microbial jungle
Charis Eng and Pauline Funchain ponder the roles of microbial diversity and microbial profiling in cancer, and consider the prospects of hunting for cancer and its causes amidst the wildlife of the human microbiome.
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Genome Medicine 2013, 5:48Gene expression in Alzheimer's
Transcriptomic and systems analyses of two brain regions in Alzheimer's disease reveals associations between disease status, transcript levels, and brain region.
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Genome Medicine 2013, 5:45European geneticists' views on DTC testing
An online survey of European clinical geneticists found high awareness of direct-to-consumer genetic testing but most participants did not agree with such testing for severe conditions.
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Featured free review
Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.
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Latest issue
The complete issue of Genome Medicine Volume 5 Issue 5 is now available.
Multimedia
Focus on metabolomics
As part of our article series on the Metabolomics of Disease, check out our interactive graphic and free podcast featuring Tim Veenstra, David Wishart and Jeremy Nicholson
Article collections
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Microbes in human health and disease
Edited by: Dr Martin L. Hibberd
Published: 29 April 2013
Last updated: 29 May 2013 -
Musings on Genome Medicine
Published: 29 April 2013
Last updated: 14 May 2013 -
Proteomic applications in medicine
Edited by: Prof Sabine Bahn, Dr Paul Guest
Published: 27 February 2013
Last updated: 30 April 2013
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