Systems medicine: learning from the past

The pioneering work of Jean Dausset on the human leukocyte antigen system provides lessons that should be applied to systems medicine.

NF-κB activation in ovarian cancer

NF-κB plays a role in the initiation and progression of ovarian cancer and represents a potential target for the development of novel therapeutics for this type of cancer.

Parent-of-origin effects in diabetes

Genetic imprinting is known to have a role in 6q24-related transient neonatal diabetes, and recent research has also revealed parent of origin effects in type I and II diabetes mellitus.

Cancer genomes: environment and mutational spectra

Whole-genome sequences of cancers reveal the different kinds of mutation caused by environmental carcinogens.

Common path to pathogen susceptibility?

Genomic research so far suggests that host susceptibility to different pathogens is controlled by discrete genes and pathways, but as technology develops it may unravel shared mechanisms across multiple pathogen groups.

Cloud computing for translational research

Cloud-based analysis offers a valid alternative both in terms of performance and cost to local computational clusters for the integration and analysis of large-scale genomic datasets relevant for translational research.

Post-genomic diagnosis of fetal aneuploidy

Non-invasive prenatal diagnosis of fetal aneuploidies may soon become possible with new genomic and proteomic technologies.

Whole proteomes as internal standards in quantitative proteomics

Pooling several proteomes labeled with stable isotopes yields an internal standard that can greatly increase the accuracy of quantitative proteomics.