Metabolomic staging of colorectal cancer

Serum metabolomic profiles change markedly with metastasis of colorectal cancer, a finding that will have clinical utility in enhancing staging accuracy and selecting the right treatment for patients.

Overcoming the limits of GWAS

Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.

A metabolomic understanding of PPARs

Julian Griffin and colleagues review the role metabolomics has played in elucidating the roles of peroxisome proliferator-activated receptors in systemic metabolism regulation.

Metabolomics: the final frontier?

Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.

Extending the human CSF metabolome

A comprehensive and quantitative update of the human cerebrospinal fluid metabolome database is provided by multi-platform analysis of multiple CSF samples and an extensive literature review.

Breast cancer metabolomics

Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.

Metabolic changes linked with TETA treatment

Metabolomic analysis of serum samples in a streptozotocin-induced diabetes rat model reveals metabolic pathways affected by treatment with oral triethylenetetramine, a potential therapy for diabetes.

Combining histology and metabolomics

A clinical workflow for concurrent metabolite extraction and histological analysis of intact tumor biopsies allows augmentation of histopathological diagnosis with quantitative biochemical measures.