Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.

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  • Rebecca Furlong, PhD,

Articles

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  • Image attributed to: From Spence et al.

    Iterative approach to hotspots

    Most current algorithms struggle to map mutational hot spots; a new approach, the Deep-Drilling with iterative Mapping (DDiMAP) method, retains variant allele patterns to aid in variant detection.

    Genome Medicine 2015, 7:24
  • Image attributed to: Human anatomy_fromiStockPhoto

    Microbiome-based therapies: believe the hype?

    As more and more links are demonstrated between the microbiome and different types of disease, Fergus Shanahan discusses how the human microbiome could provide insight into novel therapies.

    Genome Medicine 2015, 7:17
  • Sweden Cancerome Analysis Network

    Development, validation and implementation of clinically beneficial molecular tumor analyses in routine healthcare for patients with breast cancer to improve their care, quality of life and outcome.

    Genome Medicine 2015, 7:20
  • Image attributed to: Detail of Figure 1_from Charlton et al.

    Epigenetic biomarkers of Wilms tumour

    Methylome analysis of wilms tumors, nephrogenic rests and normal kidney tissues provides insight into tumor evolution and reveals potential markers to diagnose patients with bilateral disease.

    Genome Medicine 2015, 7:11
  • Image attributed to: From Fig 2 Valencia and colleagues

    CLL and gene expression variability

    A relationship between disease subtype in chronic lymphocytic leukemia and variation in gene expression suggests that variability has an effect on tumor adaptability and aggressiveness.

    Genome Medicine 2015, 7:8
  • Image attributed to: Green heart pills_from iStockPhoto

    Genetic variation and cardiovascular therapies

    Timpson and Corbin discuss how a recent study looking at inactivating mutations in NPC1L1 provides insight into therapy with ezetimibe, used to reduce plasma cholesterol levels in coronary heart disease.

    Genome Medicine 2015, 7:7
  • Image attributed to: Detail of Figure 2 from Malhotra et al.

    Ploidy-Seq: a tool to reconstruct tumor evolution

    A novel method combining flow-sorting to separate tumor populations by ploidy with high-throughput sequencing shows promise to trace genome evolution in human cancer.

    Genome Medicine 2015, 7:6
  • Image attributed to: From Fig 1 Ruklisa et al.

    APPRAISE variant pathogenicity

    Disease-specific Bayesian models provide a robust, accurate and transparent framework to integrate multiple sources of evidence for the interpretation of novel variants from gene sequencing.

    Genome Medicine 2015, 7:5

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.


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call for papers Diagnostic Genomics
genomics to diseases mechanisms
Genomics of infectious diseases: special issue
Cancer Epigenomics
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ISSN: 1756-994X