Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD,


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  • Image attributed to: From Fig 2 Valencia and colleagues

    CLL and gene expression variability

    A relationship between disease subtype in chronic lymphocytic leukemia and variation in gene expression suggests that variability has an effect on tumor adaptability and aggressiveness.

    Genome Medicine 2015, 7:8
  • Image attributed to: Green heart pills_from iStockPhoto

    Genetic variation and cardiovascular therapies

    Timpson and Corbin discuss how a recent study looking at inactivating mutations in NPC1L1 provides insight into therapy with ezetimibe, used to reduce plasma cholesterol levels in coronary heart disease.

    Genome Medicine 2015, 7:7
  • Image attributed to: Detail of Figure 2 from Malhotra et al.

    Ploidy-Seq: a tool to reconstruct tumor evolution

    A novel method combining flow-sorting to separate tumor populations by ploidy with high-throughput sequencing shows promise to trace genome evolution in human cancer.

    Genome Medicine 2015, 7:6
  • Image attributed to: From Fig 1 Ruklisa et al.

    APPRAISE variant pathogenicity

    Disease-specific Bayesian models provide a robust, accurate and transparent framework to integrate multiple sources of evidence for the interpretation of novel variants from gene sequencing.

    Genome Medicine 2015, 7:5
  • Image attributed to: From Fig 1 Lettre and colleagues

    DNA methylation map in blood cell progenitors

    Comprehensive DNA methylome maps of human erythroblasts differentiated ex vivo from CD34+ progenitor cells purified from fetal liver or bone marrow reveal widespread dynamic changes during erythropoiesis.

    Genome Medicine 2015, 7:1
  • Image attributed to: Detail of Figure 2_Guilhamon et al

    A tool for cancer epigenomics discovery

    Evaluation of patient-derived xenografts from rare and common cancers identifies it as a suitable discovery tool for cancer epigenomics.

    Genome Medicine 2014, 6:116
  • Image attributed to: Detail of Figure 4_from Malhotra et al.

    Mining biomarkers for Alzheimer's disease

    A gray zone approach combining text mining and context-specific modeling of molecular interactions underlying stages of Alzheimer's disease identifies potential biomarkers.

    Genome Medicine 2014, 6:97
  • Image attributed to: Detail of Figure 3_from Haider et al.

    Advances in pancreatic cancer prognostic

    A large retrospective meta-analysis on pancreatic ductal adenocarninoma gene expression studies reveals a 36-gene prognostic signature for patient stratification and overall survival.

    Genome Medicine 2014, 6:105

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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ISSN: 1756-994X