Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods and software tools in all areas of medicine studied from a post-genomic perspective. The journal also provides review and comment on the latest advances in translational genomics and personalized medicine, and their implications for the clinical and ethical management of human health and disease.
- Rebecca Furlong, PhD
Catherine Wu and Dan Landau review genomic studies of chronic lymphocytic leukemia, which have revealed genetic and epigenetic heterogeneity, and mutations associated with poor prognosis.
Stephan Zuchner and Toumy Guettouche discuss the advantages of a recently published approach for target sequence enrichment to be used in clinical diagnosis and highlight potential new applications.
Hong-Wen Deng and colleagues review genome-wide approaches for identifying risk factors for osteoporosis, including genome-wide association, gene expression profiling and proteomic studies.
An approach to enrich for regions of interest in the DNA, using complementary long padlock probes, shows improved accuracy and target coverage and potentially lower cost than previous methods.
Next-generation sequencing of head and neck squamous cell carcinoma uncovers genetic alterations in HPV+ and HPV- tumors, suggesting a causal role for HPV in this cancer.
Charis Eng and Pauline Funchain ponder the roles of microbial diversity and microbial profiling in cancer, and consider the prospects of hunting for cancer and its causes amidst the wildlife of the human microbiome.
Transcriptomic and systems analyses of two brain regions in Alzheimer's disease reveals associations between disease status, transcript levels, and brain region.
An online survey of European clinical geneticists found high awareness of direct-to-consumer genetic testing but most participants did not agree with such testing for severe conditions.
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