Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods and software tools in all areas of medicine studied from a post-genomic perspective. The journal also provides review and comment on the latest advances in translational genomics and personalized medicine, and their implications for the clinical and ethical management of human health and disease.
- Rebecca Furlong, PhD
Slotkin and Nishikura review recent studies of RNA editing mediated by ADAR (adenosine deaminase acting on RNA) enzymes in diseases such as cancer and neurological disorders.
Understanding population differences in genomic loci will provide insights into risk alleles for many diseases. Scott Williams discusses recent findings on inter-ethnic differences in body mass index.
Daniel Gaile and Jeffrey Miecznikowski discuss a recent study, which elucidates the best method for the analysis of outlier expression data in small studies, for biomarker prioritization.
A comparison of statistical methods for expression analysis in a personalized medicine context reveals that in small studies outlying degree methods may be a useful alternative to Zscore or Rscore.
With increasingly globalized research there is a growing need for an international harmonized ethical review process, and a Safe Harbor Framework for International Ethics Equivalency may be a solution.
Charles Swanton and colleagues discuss how microbial experimental evolution studies can help in understanding factors that influence intra-tumor heterogeneity and guide choices in the clinical setting.
Dawn Muddyman and colleagues discuss the UK10K managed-access data-sharing process that reconciles data-sharing principles with the protection of the interests of participants and data generators.
Robert Holt and colleagues review T-cell receptor sequencing (TCR-seq), highlighting recent progress in characterizing healthy and diseased TCR repertoires and the challenges for clinical applications.
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