Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD,


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  • Image attributed to: from Erdmann and colleagues

    Stem cell fingerprinting

    A robust method for cellular phenotyping in primary human mesenchymal stem cells using kinome fingerprinting to identify gene networks that characterize distinct primary cell populations.

    Genome Medicine 2015, 7:46
  • Image attributed to: From Fig 5 Dvinge and Bradley

    Intron retention in cancer

    Abnormal RNA splicing is a common characteristic of cancers and suggests  that intron-containing mRNAs contribute to the transcriptional diversity of many cancers

    Genome Medicine 2015, 7:45
  • Image attributed to: Orange for JAFFA. Credit Elkagye -   via Wikimedia Commons

    Cancer fusion detector

    JAFFA is a sensitive method to detect novel cancer fusion genes from RNA sequencing data. It is able to accurately analyse RNA sequencing data of any read length.

    Genome Medicine 2015, 7:43
  • Image attributed to: EHR algorithm from authors' figure

    Repurposing electronic health record data for genomic research

    Wei-Qi Wei and Joshua Denny review how the combination of data extracted from EHRs with high-throughput genotyping information can accelerate genomic discovery.

    Genome Medicine 2015, 7:41
  • Image attributed to: From Fig 1 Weng et al.

    Lineage of breast neoplastic proliferations

    Deep sequencing of breast neoplasms and construction of  phylogenetic trees reveal a history of clonal expansion and cell lineage heterogeneity, and suggest that PIK3CA mutations are relatively benign.

    Genome Medicine 2015, 7:28
  • Image attributed to: Image from Kumar et al.

    PGD whole genome prediction

    Rapid embryo genotyping and molecular phasing of parental genomes can be used to predict the whole genome sequence of an embryo within a timeframe suitable for fresh transfer for in vitro fertilization.

    Genome Medicine 2015, 7:35
  • Image attributed to: Prostate cancer cells from an organoid, produced by NIH

    Organoid cancer models

    Michael Cantrell and Cavlin Kuo discuss recent developments in the three-dimensional culture of organoids and their promise for both bottom-up and top-down screening to find cancer drivers.

    Genome Medicine 2015, 7:32
  • Image attributed to: From Fig 2 Franke et al.

    Genotypes from public RNA-seq data

    An approach to quantifying, normalizing and genotyping a large number of heterogeneous public RNA-seq samples to reliably identify eQTLs and allele-specific expression across many different tissues.

    Genome Medicine 2015, 7:30

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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call for papers Diagnostic Genomics
genomics to diseases mechanisms
Genomics of infectious diseases: special issue
Cancer Epigenomics


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ISSN: 1756-994X