Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD, Genome Medicine
- Louisa Flintoft, PhD, Genome Medicine
Killer-cell immunoglobulin-like receptors play roles in infection, transplantation and pregnancy, but genotyping is difficult. A new ddPCR approach could make haplotype definition routine.
Genome-wide DNA methylation analysis comparing human, chimpanzee and rhesus macaque reveals LTB4R as most epigenetically divergent human gene relative to primates.
Thousands of volunteers have signed up for the Harvard Personal Genomes Project, with its model of non-anonymous genomes. Assessment of the participants' experience provides useful examples.
Sam Hanash and Mark Schliekelman review advances in proteomic profiling of the tumor microenvironment, and discuss how recent studies are revealing insights into tumor progression and biomarker development.
Bartha Knoppers discusses the initial goals of the Global Alliance for Genomics and Health for sharing genomic and clinical data, and the challenges for international ethics harmonization.
A comprehensive analysis of somatic mutations in triple-negative lung adenocarcinoma in never-smokers reveals 27 genes, some novel and some already targetable, potentially implicated in pathogenesis.
Pleiotropic genes in T-cell associated diseases form a module of highly interconnected genes that increases disease risk and is an important source for diagnostic markers and therapeutic targets.
A systematic review of the relationship between patient engagement and healthcare outcomes in chronic disease suggests patient engagement improves health status and highlights the need for quantification.
Latest articles from Genome Biology
Genome Biology 2014, 15:107
Genome Biology 2014, 15:R50
Genome Biology 2014, 15:R49
Genome Biology 2014, 15:R48
From the blog
- 03 February 2014
- The face of medicine is changing – are we ready for the new era?