Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD,
A robust method for cellular phenotyping in primary human mesenchymal stem cells using kinome fingerprinting to identify gene networks that characterize distinct primary cell populations.
Abnormal RNA splicing is a common characteristic of cancers and suggests that intron-containing mRNAs contribute to the transcriptional diversity of many cancers
JAFFA is a sensitive method to detect novel cancer fusion genes from RNA sequencing data. It is able to accurately analyse RNA sequencing data of any read length.
Wei-Qi Wei and Joshua Denny review how the combination of data extracted from EHRs with high-throughput genotyping information can accelerate genomic discovery.
Deep sequencing of breast neoplasms and construction of phylogenetic trees reveal a history of clonal expansion and cell lineage heterogeneity, and suggest that PIK3CA mutations are relatively benign.
Rapid embryo genotyping and molecular phasing of parental genomes can be used to predict the whole genome sequence of an embryo within a timeframe suitable for fresh transfer for in vitro fertilization.
Michael Cantrell and Cavlin Kuo discuss recent developments in the three-dimensional culture of organoids and their promise for both bottom-up and top-down screening to find cancer drivers.
An approach to quantifying, normalizing and genotyping a large number of heterogeneous public RNA-seq samples to reliably identify eQTLs and allele-specific expression across many different tissues.
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