Molecular heterogeneity of CLL

Catherine Wu and Dan Landau review genomic studies of chronic lymphocytic leukemia, which have revealed genetic and epigenetic heterogeneity, and mutations associated with poor prognosis.

Limitations overcome in target enrichment

Stephan Zuchner and Toumy Guettouche discuss the advantages of a recently published approach for target sequence enrichment to be used in clinical diagnosis and highlight potential new applications.

Genome-wide studies of osteoporosis

Hong-Wen Deng and colleagues review genome-wide approaches for identifying risk factors for osteoporosis, including genome-wide association, gene expression profiling and proteomic studies.

cLPP: a new method for exome target capture

An approach to enrich for regions of interest in the DNA, using complementary long padlock probes, shows improved accuracy and target coverage and potentially lower cost than previous methods.

Sequencing of HPV+ head and neck cancer

Next-generation sequencing of head and neck squamous cell carcinoma uncovers genetic alterations in HPV+ and HPV- tumors, suggesting a causal role for HPV in this cancer.

Stalking cancer in the microbial jungle

Charis Eng and Pauline Funchain ponder the roles of microbial diversity and microbial profiling in cancer, and consider the prospects of hunting for cancer and its causes amidst the wildlife of the human microbiome.

Gene expression in Alzheimer's

Transcriptomic and systems analyses of two brain regions in Alzheimer's disease reveals associations between disease status, transcript levels, and brain region.

European geneticists' views on DTC testing

An online survey of European clinical geneticists found high awareness of direct-to-consumer genetic testing but most participants did not agree with such testing for severe conditions.